Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132582151> ?p ?o ?g. }
- W3132582151 endingPage "101309" @default.
- W3132582151 startingPage "101309" @default.
- W3132582151 abstract "Mitochondria are highly dynamic organelles capable of adapting their network, morphology, and function, playing a role in oxidative phosphorylation and many cellular processes in most cell types. Skeletal muscle is a very plastic tissue, subjected to many morphological changes following diverse stimuli, such as during myogenic differentiation and regenerative myogenesis. For some time now, mitochondria have been reported to be involved in myogenesis by promoting a bioenergetic remodeling and assisting myoblasts in surviving the process. However, not much is known about the interplay between mitochondrial quality control and myogenic differentiation. Sestrin2 (SESN2) is a well described regulator of autophagy and antioxidant responses and has been gaining attention due to its role in aging-associated pathologies and redox signaling promoted by reactive oxygen species (ROS) in many tissues. Current evidence involving SESN2-associated pathways suggest that it can act as a potential regulator of mitochondrial quality control following induction by ROS under stress conditions, such as during myogenesis. Yet, there are no studies directly assessing SESN2 involvement in myogenic differentiation. This review provides novel insights pertaining the involvement of SESN2 in myogenic differentiation by analyzing the interactions between ROS and mitochondrial remodeling." @default.
- W3132582151 created "2021-03-01" @default.
- W3132582151 creator A5018213498 @default.
- W3132582151 creator A5024381508 @default.
- W3132582151 creator A5033379702 @default.
- W3132582151 creator A5082432780 @default.
- W3132582151 date "2021-05-01" @default.
- W3132582151 modified "2023-10-15" @default.
- W3132582151 title "Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation" @default.
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