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- W3132764893 abstract "Tuberculosis is one of the 10 leading causes of death worldwide and the main cause of death from a single infectious agent, Mycobacterium tuberculosis (Mtb). Isoniazid (INH) is one of the first-line drugs to fight Mtb infections and is part of all multi-therapeutic regimens recommended by the World Health Organization. However, mutations in the enzyme KatG lead to resistance to INH. A large fraction of the new (3.5%) and previously treated (18%) tuberculosis cases exhibits multidrug resistance (MDR) and thus it is urgent to develop new effective and low toxicity antitubercular compounds." @default.
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- W3132764893 date "2021-02-01" @default.
- W3132764893 modified "2023-10-18" @default.
- W3132764893 title "Paving the Way to Fight Multi-Drug Resistant Tuberculosis" @default.
- W3132764893 doi "https://doi.org/10.1016/j.bpj.2020.11.1819" @default.
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