FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132775247> ?p ?o ?g. }

• W3132775247 abstract "Abstract The Coronavirus Disease of 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health and economy. Therapeutic options such as monoclonal antibodies (mAbs) against SARS-CoV-2 are in urgent need. We have identified potent monoclonal antibodies binding to SARS-CoV-2 Spike protein from COVID-19 convalescent patients and one of these antibodies, P4A1, interacts directly and covers the majority of the Receptor Binding Motif (RBM) of Spike receptor-binding domain (RBD), shown by high-resolution complex structure analysis. We further demonstrated P4A1 binding and neutralizing activities against wild type and mutant spike proteins. P4A1 was subsequently engineered to reduce the potential risk for antibody-dependent enhancement (ADE) of infection and to extend its half-life. The engineered mAb exhibits optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection." @default.
• W3132775247 created "2021-03-01" @default.
• W3132775247 creator A5000352121 @default.
• W3132775247 creator A5008491549 @default.
• W3132775247 creator A5011654282 @default.
• W3132775247 creator A5014398825 @default.
• W3132775247 creator A5015879369 @default.
• W3132775247 creator A5016482780 @default.
• W3132775247 creator A5017774638 @default.
• W3132775247 creator A5021682205 @default.
• W3132775247 creator A5026530336 @default.
• W3132775247 creator A5029040563 @default.
• W3132775247 creator A5029875140 @default.
• W3132775247 creator A5030126374 @default.
• W3132775247 creator A5030363713 @default.
• W3132775247 creator A5031556177 @default.
• W3132775247 creator A5032353185 @default.
• W3132775247 creator A5034382408 @default.
• W3132775247 creator A5034855502 @default.
• W3132775247 creator A5034995105 @default.
• W3132775247 creator A5035313775 @default.
• W3132775247 creator A5039185869 @default.
• W3132775247 creator A5039730132 @default.
• W3132775247 creator A5039768766 @default.
• W3132775247 creator A5040171967 @default.
• W3132775247 creator A5044672924 @default.
• W3132775247 creator A5044988420 @default.
• W3132775247 creator A5045818052 @default.
• W3132775247 creator A5046496837 @default.
• W3132775247 creator A5047470866 @default.
• W3132775247 creator A5053887136 @default.
• W3132775247 creator A5054095283 @default.
• W3132775247 creator A5055299862 @default.
• W3132775247 creator A5058089090 @default.
• W3132775247 creator A5059955952 @default.
• W3132775247 creator A5064359646 @default.
• W3132775247 creator A5065092309 @default.
• W3132775247 creator A5070814824 @default.
• W3132775247 creator A5071536141 @default.
• W3132775247 creator A5072928259 @default.
• W3132775247 creator A5075432747 @default.
• W3132775247 creator A5076150205 @default.
• W3132775247 creator A5076597781 @default.
• W3132775247 creator A5076699095 @default.
• W3132775247 creator A5076762162 @default.
• W3132775247 creator A5084978407 @default.
• W3132775247 creator A5088546765 @default.
• W3132775247 creator A5091110556 @default.
• W3132775247 creator A5091870178 @default.
• W3132775247 date "2020-11-14" @default.
• W3132775247 modified "2023-10-12" @default.
• W3132775247 title "A SARS-CoV-2 neutralizing antibody with exceptional spike binding coverage and optimized therapeutic potentials" @default.
• W3132775247 doi "https://doi.org/10.21203/rs.3.rs-78945/v1" @default.
• W3132775247 hasPublicationYear "2020" @default.
• W3132775247 type Work @default.
• W3132775247 sameAs 3132775247 @default.
• W3132775247 citedByCount "2" @default.
• W3132775247 countsByYear W31327752472021 @default.
• W3132775247 crossrefType "posted-content" @default.
• W3132775247 hasAuthorship W3132775247A5000352121 @default.
• W3132775247 hasAuthorship W3132775247A5008491549 @default.
• W3132775247 hasAuthorship W3132775247A5011654282 @default.
• W3132775247 hasAuthorship W3132775247A5014398825 @default.
• W3132775247 hasAuthorship W3132775247A5015879369 @default.
• W3132775247 hasAuthorship W3132775247A5016482780 @default.
• W3132775247 hasAuthorship W3132775247A5017774638 @default.
• W3132775247 hasAuthorship W3132775247A5021682205 @default.
• W3132775247 hasAuthorship W3132775247A5026530336 @default.
• W3132775247 hasAuthorship W3132775247A5029040563 @default.
• W3132775247 hasAuthorship W3132775247A5029875140 @default.
• W3132775247 hasAuthorship W3132775247A5030126374 @default.
• W3132775247 hasAuthorship W3132775247A5030363713 @default.
• W3132775247 hasAuthorship W3132775247A5031556177 @default.
• W3132775247 hasAuthorship W3132775247A5032353185 @default.
• W3132775247 hasAuthorship W3132775247A5034382408 @default.
• W3132775247 hasAuthorship W3132775247A5034855502 @default.
• W3132775247 hasAuthorship W3132775247A5034995105 @default.
• W3132775247 hasAuthorship W3132775247A5035313775 @default.
• W3132775247 hasAuthorship W3132775247A5039185869 @default.
• W3132775247 hasAuthorship W3132775247A5039730132 @default.
• W3132775247 hasAuthorship W3132775247A5039768766 @default.
• W3132775247 hasAuthorship W3132775247A5040171967 @default.
• W3132775247 hasAuthorship W3132775247A5044672924 @default.
• W3132775247 hasAuthorship W3132775247A5044988420 @default.
• W3132775247 hasAuthorship W3132775247A5045818052 @default.
• W3132775247 hasAuthorship W3132775247A5046496837 @default.
• W3132775247 hasAuthorship W3132775247A5047470866 @default.
• W3132775247 hasAuthorship W3132775247A5053887136 @default.
• W3132775247 hasAuthorship W3132775247A5054095283 @default.
• W3132775247 hasAuthorship W3132775247A5055299862 @default.
• W3132775247 hasAuthorship W3132775247A5058089090 @default.
• W3132775247 hasAuthorship W3132775247A5059955952 @default.
• W3132775247 hasAuthorship W3132775247A5064359646 @default.
• W3132775247 hasAuthorship W3132775247A5065092309 @default.
• W3132775247 hasAuthorship W3132775247A5070814824 @default.
• W3132775247 hasAuthorship W3132775247A5071536141 @default.
• W3132775247 hasAuthorship W3132775247A5072928259 @default.
• W3132775247 hasAuthorship W3132775247A5075432747 @default.
• W3132775247 hasAuthorship W3132775247A5076150205 @default.
• W3132775247 hasAuthorship W3132775247A5076597781 @default.

• next