Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132786987> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3132786987 abstract "Aim: Efavirenz is still widely used as the preferred first-line antiretroviral agent in the middle- and low- income countries, including Malaysia. The efavirenz population pharmacokinetic profile among HIV-positive smokers is still unknown. We aimed to assess the association of smoking with efavirenz and the differences in HIV clinical outcomes. Methods: A total of 154 stable HIV-positive patients on efavirenz in northern Malaysia were recruited with a sparse sampling for this multicentre prospective cohort study. The association between smoking and efavirenz pharmacokinetic parameters was determined using the non-linear mixed-effect model (NONMEM). A mixture model of clearance was adopted to describe the metaboliser status because genetic data is unavailable. The effect of smoking on HIV clinical markers (CD4, CD4 / CD8 ratio and viral blips) for at least two years after the antiretroviral initiation was also investigated. Results: Our data were best fitted with a one-compartment mixture model with first-order absorption without lag time. Smoking significantly associated with higher clearance (CL/F) (β = 1.39; 95% confidence interval (CI): 1.07 to 1.91), while weight affected both CL/F and volume (V/F). From the mixture model, 20% of patients were in the slow clearance group, which mimic the genotype distribution of slow metaboliser. An efavirenz dose reduction is not recommended for smokers ≥60kg with normal metabolism rate. Smoking significantly associated with slower normalisation of CD4 and CD4 / CD8 ratio. Conclusion: HIV-positive smokers presented with significantly higher efavirenz clearance and unfavourable clinical outcomes. Close monitoring of adherence and clinical response among smokers is warranted." @default.
- W3132786987 created "2021-03-01" @default.
- W3132786987 creator A5012579751 @default.
- W3132786987 creator A5014598869 @default.
- W3132786987 creator A5040103789 @default.
- W3132786987 creator A5043688060 @default.
- W3132786987 creator A5044486827 @default.
- W3132786987 creator A5080673715 @default.
- W3132786987 date "2020-11-24" @default.
- W3132786987 modified "2023-09-27" @default.
- W3132786987 title "The Association between Cigarette Smoking and Efavirenz Plasma Concentration using the Population Pharmacokinetic Approach" @default.
- W3132786987 doi "https://doi.org/10.22541/au.160622302.27663338/v1" @default.
- W3132786987 hasPublicationYear "2020" @default.
- W3132786987 type Work @default.
- W3132786987 sameAs 3132786987 @default.
- W3132786987 citedByCount "0" @default.
- W3132786987 crossrefType "posted-content" @default.
- W3132786987 hasAuthorship W3132786987A5012579751 @default.
- W3132786987 hasAuthorship W3132786987A5014598869 @default.
- W3132786987 hasAuthorship W3132786987A5040103789 @default.
- W3132786987 hasAuthorship W3132786987A5043688060 @default.
- W3132786987 hasAuthorship W3132786987A5044486827 @default.
- W3132786987 hasAuthorship W3132786987A5080673715 @default.
- W3132786987 hasBestOaLocation W31327869871 @default.
- W3132786987 hasConcept C112705442 @default.
- W3132786987 hasConcept C126322002 @default.
- W3132786987 hasConcept C142462285 @default.
- W3132786987 hasConcept C159047783 @default.
- W3132786987 hasConcept C2776239304 @default.
- W3132786987 hasConcept C2781432083 @default.
- W3132786987 hasConcept C2908647359 @default.
- W3132786987 hasConcept C2993143319 @default.
- W3132786987 hasConcept C3013748606 @default.
- W3132786987 hasConcept C44249647 @default.
- W3132786987 hasConcept C71924100 @default.
- W3132786987 hasConcept C90924648 @default.
- W3132786987 hasConcept C98274493 @default.
- W3132786987 hasConcept C99454951 @default.
- W3132786987 hasConceptScore W3132786987C112705442 @default.
- W3132786987 hasConceptScore W3132786987C126322002 @default.
- W3132786987 hasConceptScore W3132786987C142462285 @default.
- W3132786987 hasConceptScore W3132786987C159047783 @default.
- W3132786987 hasConceptScore W3132786987C2776239304 @default.
- W3132786987 hasConceptScore W3132786987C2781432083 @default.
- W3132786987 hasConceptScore W3132786987C2908647359 @default.
- W3132786987 hasConceptScore W3132786987C2993143319 @default.
- W3132786987 hasConceptScore W3132786987C3013748606 @default.
- W3132786987 hasConceptScore W3132786987C44249647 @default.
- W3132786987 hasConceptScore W3132786987C71924100 @default.
- W3132786987 hasConceptScore W3132786987C90924648 @default.
- W3132786987 hasConceptScore W3132786987C98274493 @default.
- W3132786987 hasConceptScore W3132786987C99454951 @default.
- W3132786987 hasLocation W31327869871 @default.
- W3132786987 hasLocation W31327869872 @default.
- W3132786987 hasOpenAccess W3132786987 @default.
- W3132786987 hasPrimaryLocation W31327869871 @default.
- W3132786987 hasRelatedWork W1987705191 @default.
- W3132786987 hasRelatedWork W2012369574 @default.
- W3132786987 hasRelatedWork W2020252702 @default.
- W3132786987 hasRelatedWork W2039830992 @default.
- W3132786987 hasRelatedWork W2087821742 @default.
- W3132786987 hasRelatedWork W2090885070 @default.
- W3132786987 hasRelatedWork W2113956288 @default.
- W3132786987 hasRelatedWork W2945177747 @default.
- W3132786987 hasRelatedWork W3013984550 @default.
- W3132786987 hasRelatedWork W3198478050 @default.
- W3132786987 isParatext "false" @default.
- W3132786987 isRetracted "false" @default.
- W3132786987 magId "3132786987" @default.
- W3132786987 workType "article" @default.