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• W3132811748 abstract "Abstract Low procalcitonin (PCT) concentrations (<0.5ng/mL) can facilitate exclusion of bacterial co-infection in viral infections, including COVID-19. However, costs associated with PCT measurement preclude universal adoption, indicating a need to identify settings where PCT provides clinical information beyond that offered by other inflammatory markers, such as C-reactive protein (CRP) and white cell count (WCC). In an unselected cohort of 299 COVID-19 patients, we tested the hypothesis that PCT<0.5ng/mL was associated with lower levels of CRP and WCC. We demonstrated that CRP values below the geometric mean of the entire patient population had a negative predictive value for PCT<0.5ng/mL of 97.6% and 100% at baseline and 48 hours into admission respectively, and that this relationship was not confounded by intensive care admission or microbiological findings. CRP-guided PCT testing algorithms can reduce costs and support antimicrobial stewardship strategies in COVID-19." @default.
• W3132811748 created "2021-03-01" @default.
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• W3132811748 date "2021-02-12" @default.
• W3132811748 modified "2023-10-05" @default.
• W3132811748 title "C-reactive protein guided use of procalcitonin in COVID-19" @default.
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• W3132811748 doi "https://doi.org/10.1101/2021.02.10.21251350" @default.
• W3132811748 hasPublicationYear "2021" @default.
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