FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132836732> ?p ?o ?g. }

• W3132836732 endingPage "1963" @default.
• W3132836732 startingPage "1955" @default.
• W3132836732 abstract "Abstract Purpose To date there has not been an extensive analysis of the outcomes of biomarker use in oncology. Methods Data were pooled across four indications in oncology drawing upon trial outcomes from www.clinicaltrials.gov : breast cancer, non‐small cell lung cancer (NSCLC), melanoma and colorectal cancer from 1998 to 2017. We compared the likelihood drugs would progress through the stages of clinical trial testing to approval based on biomarker status. This was done with multi‐state Markov models, tools that describe the stochastic process in which subjects move among a finite number of states. Results Over 10000 trials were screened, which yielded 745 drugs. The inclusion of biomarker status as a covariate significantly improved the fit of the Markov model in describing the drug trajectories through clinical trial testing stages. Hazard ratios based on the Markov models revealed the likelihood of drug approval with biomarkers having nearly a fivefold increase for all indications combined. A 12, 8 and 7‐fold hazard ratio was observed for breast cancer, melanoma and NSCLC, respectively. Markov models with exploratory biomarkers outperformed Markov models with no biomarkers. Conclusion This is the first systematic statistical evidence that biomarkers clearly increase clinical trial success rates in three different indications in oncology. Also, exploratory biomarkers, long before they are properly validated, appear to improve success rates in oncology. This supports early and aggressive adoption of biomarkers in oncology clinical trials." @default.
• W3132836732 created "2021-03-01" @default.
• W3132836732 creator A5001162127 @default.
• W3132836732 creator A5009971978 @default.
• W3132836732 creator A5010025847 @default.
• W3132836732 creator A5018568019 @default.
• W3132836732 creator A5027153964 @default.
• W3132836732 creator A5027209386 @default.
• W3132836732 creator A5060454700 @default.
• W3132836732 creator A5063719386 @default.
• W3132836732 creator A5067265616 @default.
• W3132836732 creator A5068401391 @default.
• W3132836732 creator A5078161349 @default.
• W3132836732 creator A5080569424 @default.
• W3132836732 creator A5091598445 @default.
• W3132836732 date "2021-02-23" @default.
• W3132836732 modified "2023-09-23" @default.
• W3132836732 title "Does biomarker use in oncology improve clinical trial failure risk? A large‐scale analysis" @default.
• W3132836732 cites W1489904087 @default.
• W3132836732 cites W1496135731 @default.
• W3132836732 cites W1588959571 @default.
• W3132836732 cites W1919480245 @default.
• W3132836732 cites W1989440761 @default.
• W3132836732 cites W2002952222 @default.
• W3132836732 cites W2009929157 @default.
• W3132836732 cites W2028688785 @default.
• W3132836732 cites W2071848682 @default.
• W3132836732 cites W2088229392 @default.
• W3132836732 cites W2108468456 @default.
• W3132836732 cites W2114281628 @default.
• W3132836732 cites W2114829023 @default.
• W3132836732 cites W2134787029 @default.
• W3132836732 cites W2318605753 @default.
• W3132836732 cites W2329648702 @default.
• W3132836732 cites W4232029634 @default.
• W3132836732 doi "https://doi.org/10.1002/cam4.3732" @default.
• W3132836732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7957156" @default.
• W3132836732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33620160" @default.
• W3132836732 hasPublicationYear "2021" @default.
• W3132836732 type Work @default.
• W3132836732 sameAs 3132836732 @default.
• W3132836732 citedByCount "13" @default.
• W3132836732 countsByYear W31328367322021 @default.
• W3132836732 countsByYear W31328367322022 @default.
• W3132836732 countsByYear W31328367322023 @default.
• W3132836732 crossrefType "journal-article" @default.
• W3132836732 hasAuthorship W3132836732A5001162127 @default.
• W3132836732 hasAuthorship W3132836732A5009971978 @default.
• W3132836732 hasAuthorship W3132836732A5010025847 @default.
• W3132836732 hasAuthorship W3132836732A5018568019 @default.
• W3132836732 hasAuthorship W3132836732A5027153964 @default.
• W3132836732 hasAuthorship W3132836732A5027209386 @default.
• W3132836732 hasAuthorship W3132836732A5060454700 @default.
• W3132836732 hasAuthorship W3132836732A5063719386 @default.
• W3132836732 hasAuthorship W3132836732A5067265616 @default.
• W3132836732 hasAuthorship W3132836732A5068401391 @default.
• W3132836732 hasAuthorship W3132836732A5078161349 @default.
• W3132836732 hasAuthorship W3132836732A5080569424 @default.
• W3132836732 hasAuthorship W3132836732A5091598445 @default.
• W3132836732 hasBestOaLocation W31328367322 @default.
• W3132836732 hasConcept C121608353 @default.
• W3132836732 hasConcept C126322002 @default.
• W3132836732 hasConcept C143998085 @default.
• W3132836732 hasConcept C185592680 @default.
• W3132836732 hasConcept C207103383 @default.
• W3132836732 hasConcept C2776256026 @default.
• W3132836732 hasConcept C2781197716 @default.
• W3132836732 hasConcept C44249647 @default.
• W3132836732 hasConcept C530470458 @default.
• W3132836732 hasConcept C535046627 @default.
• W3132836732 hasConcept C55493867 @default.
• W3132836732 hasConcept C71924100 @default.
• W3132836732 hasConceptScore W3132836732C121608353 @default.
• W3132836732 hasConceptScore W3132836732C126322002 @default.
• W3132836732 hasConceptScore W3132836732C143998085 @default.
• W3132836732 hasConceptScore W3132836732C185592680 @default.
• W3132836732 hasConceptScore W3132836732C207103383 @default.
• W3132836732 hasConceptScore W3132836732C2776256026 @default.
• W3132836732 hasConceptScore W3132836732C2781197716 @default.
• W3132836732 hasConceptScore W3132836732C44249647 @default.
• W3132836732 hasConceptScore W3132836732C530470458 @default.
• W3132836732 hasConceptScore W3132836732C535046627 @default.
• W3132836732 hasConceptScore W3132836732C55493867 @default.
• W3132836732 hasConceptScore W3132836732C71924100 @default.
• W3132836732 hasIssue "6" @default.
• W3132836732 hasLocation W31328367321 @default.
• W3132836732 hasLocation W31328367322 @default.
• W3132836732 hasOpenAccess W3132836732 @default.
• W3132836732 hasPrimaryLocation W31328367321 @default.
• W3132836732 hasRelatedWork W1979901014 @default.
• W3132836732 hasRelatedWork W2050875047 @default.
• W3132836732 hasRelatedWork W2224319365 @default.
• W3132836732 hasRelatedWork W2340130805 @default.
• W3132836732 hasRelatedWork W2494271427 @default.
• W3132836732 hasRelatedWork W2795180021 @default.
• W3132836732 hasRelatedWork W2909399418 @default.
• W3132836732 hasRelatedWork W2944437644 @default.
• W3132836732 hasRelatedWork W3125223002 @default.

• next