FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132855401> ?p ?o ?g. }

• W3132855401 abstract "Paclitaxel is a widely prescribed chemotherapy drug for treating solid tumors. However, paclitaxel-induced peripheral neuropathy (PIPN) is a common adverse effect during paclitaxel treatment, which results in sensory abnormalities and neuropathic pain among patients. Unfortunately, the mechanisms underlying PIPN still remain poorly understood. Long noncoding RNAs (lncRNAs) are novel and promising targets for chronic pain treatment, but their involvement in PIPN still remains unexplored.We established a rat PIPN model by repetitive paclitaxel application. Immunostaining, RNA sequencing (RNA-Seq) and bioinformatics analysis were performed to study glia cell activation and explore lncRNA/mRNA expression profiles in spinal cord dorsal horn (SCDH) of PIPN model rats. qPCR and protein assay were used for further validation.PIPN model rats developed long-lasting mechanical and thermal pain hypersensitivities in hind paws, accompanied with astrocyte and microglia activation in SCDH. RNA-Seq identified a total of 814 differentially expressed mRNAs (DEmRNA) (including 467 upregulated and 347 downregulated) and 412 DElncRNAs (including 145 upregulated and 267 downregulated) in SCDH of PIPN model rats vs. control rats. Functional analysis of DEmRNAs and DElncRNAs identified that the most significantly enriched pathways include immune/inflammatory responses and neurotrophin signaling pathways, which are all important mechanisms mediating neuroinflammation, central sensitization, and chronic pain. We further compared our dataset with other published datasets of neuropathic pain and identified a core set of immune response-related genes extensively involved in PIPN and other neuropathic pain conditions. Lastly, a competing RNA network analysis of DElncRNAs and DEmRNAs was performed to identify potential regulatory networks of lncRNAs on mRNA through miRNA sponging.Our study provided the transcriptome profiling of DElncRNAs and DEmRNAs and uncovered immune and inflammatory responses were predominant biological events in SCDH of the rat PIPN model. Thus, our study may help to identify promising genes or signaling pathways for PIPN therapeutics." @default.
• W3132855401 created "2021-03-01" @default.
• W3132855401 creator A5011600927 @default.
• W3132855401 creator A5017878330 @default.
• W3132855401 creator A5027624175 @default.
• W3132855401 creator A5036609300 @default.
• W3132855401 creator A5042079141 @default.
• W3132855401 creator A5045478990 @default.
• W3132855401 creator A5054512613 @default.
• W3132855401 creator A5074960915 @default.
• W3132855401 creator A5075180888 @default.
• W3132855401 creator A5075877965 @default.
• W3132855401 creator A5077086042 @default.
• W3132855401 creator A5085560837 @default.
• W3132855401 creator A5090313289 @default.
• W3132855401 date "2021-02-18" @default.
• W3132855401 modified "2023-10-14" @default.
• W3132855401 title "Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and pain" @default.
• W3132855401 cites W1991677710 @default.
• W3132855401 cites W1999574084 @default.
• W3132855401 cites W2004980946 @default.
• W3132855401 cites W2053242178 @default.
• W3132855401 cites W2060424507 @default.
• W3132855401 cites W2066231767 @default.
• W3132855401 cites W2068728516 @default.
• W3132855401 cites W2069500071 @default.
• W3132855401 cites W2077829193 @default.
• W3132855401 cites W2102278945 @default.
• W3132855401 cites W2103351070 @default.
• W3132855401 cites W2107277218 @default.
• W3132855401 cites W2134495718 @default.
• W3132855401 cites W2139760555 @default.
• W3132855401 cites W2140441724 @default.
• W3132855401 cites W2147597595 @default.
• W3132855401 cites W2153241779 @default.
• W3132855401 cites W2155966056 @default.
• W3132855401 cites W2156274673 @default.
• W3132855401 cites W2159675211 @default.
• W3132855401 cites W2163413806 @default.
• W3132855401 cites W2170551349 @default.
• W3132855401 cites W2172201406 @default.
• W3132855401 cites W2179438025 @default.
• W3132855401 cites W2184694295 @default.
• W3132855401 cites W2184997675 @default.
• W3132855401 cites W2198153867 @default.
• W3132855401 cites W2234168863 @default.
• W3132855401 cites W2290321013 @default.
• W3132855401 cites W2294088168 @default.
• W3132855401 cites W2472921249 @default.
• W3132855401 cites W2541757731 @default.
• W3132855401 cites W2547814918 @default.
• W3132855401 cites W2574982197 @default.
• W3132855401 cites W2590176253 @default.
• W3132855401 cites W2620036274 @default.
• W3132855401 cites W2737697856 @default.
• W3132855401 cites W2742362032 @default.
• W3132855401 cites W2746859670 @default.
• W3132855401 cites W2750084680 @default.
• W3132855401 cites W2751792485 @default.
• W3132855401 cites W2762851710 @default.
• W3132855401 cites W2767667746 @default.
• W3132855401 cites W2783960711 @default.
• W3132855401 cites W2784570320 @default.
• W3132855401 cites W2793532375 @default.
• W3132855401 cites W2795126113 @default.
• W3132855401 cites W2887408433 @default.
• W3132855401 cites W2890517686 @default.
• W3132855401 cites W2898072735 @default.
• W3132855401 cites W2898182084 @default.
• W3132855401 cites W2900219832 @default.
• W3132855401 cites W2900932032 @default.
• W3132855401 cites W2905868894 @default.
• W3132855401 cites W2914860566 @default.
• W3132855401 cites W2919654307 @default.
• W3132855401 cites W2938163414 @default.
• W3132855401 cites W2938939321 @default.
• W3132855401 cites W2939152062 @default.
• W3132855401 cites W2940721099 @default.
• W3132855401 cites W2946679370 @default.
• W3132855401 cites W2950958458 @default.
• W3132855401 cites W2988364831 @default.
• W3132855401 cites W2989575247 @default.
• W3132855401 cites W2991011386 @default.
• W3132855401 cites W3003405277 @default.
• W3132855401 cites W3008269140 @default.
• W3132855401 cites W3021363784 @default.
• W3132855401 cites W3024060187 @default.
• W3132855401 cites W3026041669 @default.
• W3132855401 cites W3027271186 @default.
• W3132855401 cites W3035936393 @default.
• W3132855401 cites W3077754188 @default.
• W3132855401 cites W3094376376 @default.
• W3132855401 cites W3095404880 @default.
• W3132855401 doi "https://doi.org/10.1186/s12974-021-02098-y" @default.
• W3132855401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7890637" @default.
• W3132855401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33602238" @default.
• W3132855401 hasPublicationYear "2021" @default.
• W3132855401 type Work @default.
• W3132855401 sameAs 3132855401 @default.
• W3132855401 citedByCount "29" @default.

• next