FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132912333> ?p ?o ?g. }

• W3132912333 endingPage "986" @default.
• W3132912333 startingPage "979" @default.
• W3132912333 abstract "Abstract High-dose methotrexate (HD-MTX) at 3 g/m 2 is one of the strategies for central nervous system (CNS) prophylaxis in the first-line treatment of aggressive lymphomas, especially in diffuse large B cell lymphoma patients with high-risk CNS-International Prognostic Index. The objective of our study was to retrospectively analyze the safety of 2 cycles of systemic HD-MTX administered as an ambulatory regimen. Between January 2013 and December 2016, 103 patients were carefully selected on 6 criteria, including age < 60, albumin > 34, performance status 0 or 1, normal renal and hepatic functions, good understanding of practical medical guidance, and no loss of weight. Strict procedures of HD-MTX infusion were observed including alkalinization, urine pH monitoring, and leucovorin rescue. Renal and hepatic functions were monitored at days 2 and 7. MTX clearance was not monitored. Toxicities and grades of toxicity were collected according to the NCI-CTCAE (version 4.0). Among the 103 selected patients, 92 (89%) patients successfully completed the planned 2 cycles of HD-MTX on an outpatient basis. Eleven patients completed only 1 cycle, 3 because of lymphoma progression and 8 because of toxicity including 3 grade II hepatotoxicity, 2 grade I/II renal toxicity, 1 grade III neutropenia, 1 active herpetic infection, and 1 grade III ileus reflex. Reported adverse events (AE) included 92 (84%) grade I/II and 18 (16%) grade III/IV. Grade III hepatotoxicity, mostly cytolysis, was the most frequent AE observed with 8 (8%) events. Grade III/IV hematologic toxicities concerned 9 patients with 8 grade III/IV neutropenia and 1 thrombocytopenia. Renal toxicity was rare, mild, and transient, observed with 4 (4%) grade I/II events. Ambulatory administration of HD-MTX at 3 g/m 2 without MTX clearance monitoring is safe with strict medical guidance. It requires careful selection of patients before administration, and a renal and hepatic monitoring after the administration." @default.
• W3132912333 created "2021-03-01" @default.
• W3132912333 creator A5009860309 @default.
• W3132912333 creator A5013143344 @default.
• W3132912333 creator A5033073385 @default.
• W3132912333 creator A5036088286 @default.
• W3132912333 creator A5051792975 @default.
• W3132912333 creator A5052359098 @default.
• W3132912333 creator A5056514957 @default.
• W3132912333 creator A5061720810 @default.
• W3132912333 creator A5065873043 @default.
• W3132912333 creator A5078712790 @default.
• W3132912333 creator A5089012773 @default.
• W3132912333 date "2021-02-19" @default.
• W3132912333 modified "2023-10-16" @default.
• W3132912333 title "Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma" @default.
• W3132912333 cites W1993442932 @default.
• W3132912333 cites W1995939575 @default.
• W3132912333 cites W2002640309 @default.
• W3132912333 cites W2029065958 @default.
• W3132912333 cites W2045786089 @default.
• W3132912333 cites W2046750551 @default.
• W3132912333 cites W2058015212 @default.
• W3132912333 cites W2098676147 @default.
• W3132912333 cites W2118684974 @default.
• W3132912333 cites W2119147717 @default.
• W3132912333 cites W2123971450 @default.
• W3132912333 cites W2126779872 @default.
• W3132912333 cites W2132500976 @default.
• W3132912333 cites W2133902485 @default.
• W3132912333 cites W2154868392 @default.
• W3132912333 cites W2162693374 @default.
• W3132912333 cites W2167425679 @default.
• W3132912333 cites W2168446621 @default.
• W3132912333 cites W2170312313 @default.
• W3132912333 cites W2226649616 @default.
• W3132912333 cites W2310716991 @default.
• W3132912333 cites W2336134391 @default.
• W3132912333 cites W2338213887 @default.
• W3132912333 cites W2462981464 @default.
• W3132912333 cites W2493103431 @default.
• W3132912333 cites W2514966489 @default.
• W3132912333 cites W2556517183 @default.
• W3132912333 cites W2734666624 @default.
• W3132912333 cites W2758897838 @default.
• W3132912333 cites W2763709585 @default.
• W3132912333 cites W2766169840 @default.
• W3132912333 cites W2775519611 @default.
• W3132912333 cites W2778392516 @default.
• W3132912333 cites W2792674697 @default.
• W3132912333 cites W2944839297 @default.
• W3132912333 cites W2949002175 @default.
• W3132912333 doi "https://doi.org/10.1007/s00277-020-04341-7" @default.
• W3132912333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7960588" @default.
• W3132912333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33608849" @default.
• W3132912333 hasPublicationYear "2021" @default.
• W3132912333 type Work @default.
• W3132912333 sameAs 3132912333 @default.
• W3132912333 citedByCount "7" @default.
• W3132912333 countsByYear W31329123332021 @default.
• W3132912333 countsByYear W31329123332022 @default.
• W3132912333 crossrefType "journal-article" @default.
• W3132912333 hasAuthorship W3132912333A5009860309 @default.
• W3132912333 hasAuthorship W3132912333A5013143344 @default.
• W3132912333 hasAuthorship W3132912333A5033073385 @default.
• W3132912333 hasAuthorship W3132912333A5036088286 @default.
• W3132912333 hasAuthorship W3132912333A5051792975 @default.
• W3132912333 hasAuthorship W3132912333A5052359098 @default.
• W3132912333 hasAuthorship W3132912333A5056514957 @default.
• W3132912333 hasAuthorship W3132912333A5061720810 @default.
• W3132912333 hasAuthorship W3132912333A5065873043 @default.
• W3132912333 hasAuthorship W3132912333A5078712790 @default.
• W3132912333 hasAuthorship W3132912333A5089012773 @default.
• W3132912333 hasBestOaLocation W31329123331 @default.
• W3132912333 hasConcept C126322002 @default.
• W3132912333 hasConcept C141071460 @default.
• W3132912333 hasConcept C194409129 @default.
• W3132912333 hasConcept C197934379 @default.
• W3132912333 hasConcept C2777063308 @default.
• W3132912333 hasConcept C2778850193 @default.
• W3132912333 hasConcept C2781059491 @default.
• W3132912333 hasConcept C2781413609 @default.
• W3132912333 hasConcept C29730261 @default.
• W3132912333 hasConcept C71924100 @default.
• W3132912333 hasConcept C90924648 @default.
• W3132912333 hasConceptScore W3132912333C126322002 @default.
• W3132912333 hasConceptScore W3132912333C141071460 @default.
• W3132912333 hasConceptScore W3132912333C194409129 @default.
• W3132912333 hasConceptScore W3132912333C197934379 @default.
• W3132912333 hasConceptScore W3132912333C2777063308 @default.
• W3132912333 hasConceptScore W3132912333C2778850193 @default.
• W3132912333 hasConceptScore W3132912333C2781059491 @default.
• W3132912333 hasConceptScore W3132912333C2781413609 @default.
• W3132912333 hasConceptScore W3132912333C29730261 @default.
• W3132912333 hasConceptScore W3132912333C71924100 @default.
• W3132912333 hasConceptScore W3132912333C90924648 @default.
• W3132912333 hasIssue "4" @default.
• W3132912333 hasLocation W31329123331 @default.

• next