Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132912598> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3132912598 endingPage "111654" @default.
- W3132912598 startingPage "111654" @default.
- W3132912598 abstract "Bioconjugate gold-based nanostructures combining the plasmonic photothermal effect with photothermal-triggered DNA delivery are appealing materials for medical diagnostic and therapy for cell-based disease. In this study, we demonstrate the use of surface hybridization to prepare DNA-modified gold nanorods to be used as photo-delivery system for single stranded oligonucleotides. The as prepared DNA modified gold nanorods have strong absorption bands in the visible and near-infrared regions in which the absorbed light through photothermal effect, induces a surface temperature increasing up to the melting temperature with consequent DNA release. No evident DNA release was observed below the melting temperature. The experimental data were supported by molecular dynamic simulation investigation, showing the kinetics aspect of dsDNA de-hybridization at gold nanorods surface at temperature below (298 K) and above (333 K) the melting temperature of sequence investigated. We demonstrate that the cationic charges of surfactant, localized at nanorods surface, induce a remarkable de-hybridization of strands DNA, as confirmed by an increasing of hybridization enthalpy value of about 7 kcal/mol and by a faster de-hybridization process, respect the model of gold nanorods without positive charges. These data were corroborated by the increasing of the root mean square deviation value (about 4.4 Å, calculated at 333 K) indicating that the presence of cationic headgroup at gold surface induce separation of the double strand. This finding data paving the way for the development of nanostructured material for photothermal-triggered delivery systems of DNA for gene therapy application." @default.
- W3132912598 created "2021-03-01" @default.
- W3132912598 creator A5004251536 @default.
- W3132912598 creator A5005143396 @default.
- W3132912598 creator A5057049795 @default.
- W3132912598 creator A5087351341 @default.
- W3132912598 creator A5088850963 @default.
- W3132912598 date "2021-05-01" @default.
- W3132912598 modified "2023-09-26" @default.
- W3132912598 title "Photothermal-triggered system for oligonucleotides delivery from cationic gold nanorods surface: A molecular dynamic investigation" @default.
- W3132912598 cites W1031578623 @default.
- W3132912598 cites W1903778810 @default.
- W3132912598 cites W1972962953 @default.
- W3132912598 cites W1998882765 @default.
- W3132912598 cites W1999386415 @default.
- W3132912598 cites W2010467127 @default.
- W3132912598 cites W2013835226 @default.
- W3132912598 cites W2022268913 @default.
- W3132912598 cites W2028845434 @default.
- W3132912598 cites W2031171780 @default.
- W3132912598 cites W2044560021 @default.
- W3132912598 cites W2060676738 @default.
- W3132912598 cites W2076719191 @default.
- W3132912598 cites W2083409726 @default.
- W3132912598 cites W2087149563 @default.
- W3132912598 cites W2103098225 @default.
- W3132912598 cites W2147371464 @default.
- W3132912598 cites W2164570187 @default.
- W3132912598 cites W2204959575 @default.
- W3132912598 cites W2748181778 @default.
- W3132912598 cites W2884602597 @default.
- W3132912598 cites W2899461675 @default.
- W3132912598 cites W2983370016 @default.
- W3132912598 cites W2984671881 @default.
- W3132912598 cites W2995511614 @default.
- W3132912598 cites W3008247200 @default.
- W3132912598 cites W3013988004 @default.
- W3132912598 doi "https://doi.org/10.1016/j.colsurfb.2021.111654" @default.
- W3132912598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33657517" @default.
- W3132912598 hasPublicationYear "2021" @default.
- W3132912598 type Work @default.
- W3132912598 sameAs 3132912598 @default.
- W3132912598 citedByCount "7" @default.
- W3132912598 countsByYear W31329125982021 @default.
- W3132912598 countsByYear W31329125982022 @default.
- W3132912598 countsByYear W31329125982023 @default.
- W3132912598 crossrefType "journal-article" @default.
- W3132912598 hasAuthorship W3132912598A5004251536 @default.
- W3132912598 hasAuthorship W3132912598A5005143396 @default.
- W3132912598 hasAuthorship W3132912598A5057049795 @default.
- W3132912598 hasAuthorship W3132912598A5087351341 @default.
- W3132912598 hasAuthorship W3132912598A5088850963 @default.
- W3132912598 hasConcept C126201875 @default.
- W3132912598 hasConcept C127413603 @default.
- W3132912598 hasConcept C129312508 @default.
- W3132912598 hasConcept C171250308 @default.
- W3132912598 hasConcept C182606246 @default.
- W3132912598 hasConcept C183882617 @default.
- W3132912598 hasConcept C185592680 @default.
- W3132912598 hasConcept C188027245 @default.
- W3132912598 hasConcept C192562407 @default.
- W3132912598 hasConcept C2777742735 @default.
- W3132912598 hasConcept C42360764 @default.
- W3132912598 hasConcept C552990157 @default.
- W3132912598 hasConcept C55493867 @default.
- W3132912598 hasConceptScore W3132912598C126201875 @default.
- W3132912598 hasConceptScore W3132912598C127413603 @default.
- W3132912598 hasConceptScore W3132912598C129312508 @default.
- W3132912598 hasConceptScore W3132912598C171250308 @default.
- W3132912598 hasConceptScore W3132912598C182606246 @default.
- W3132912598 hasConceptScore W3132912598C183882617 @default.
- W3132912598 hasConceptScore W3132912598C185592680 @default.
- W3132912598 hasConceptScore W3132912598C188027245 @default.
- W3132912598 hasConceptScore W3132912598C192562407 @default.
- W3132912598 hasConceptScore W3132912598C2777742735 @default.
- W3132912598 hasConceptScore W3132912598C42360764 @default.
- W3132912598 hasConceptScore W3132912598C552990157 @default.
- W3132912598 hasConceptScore W3132912598C55493867 @default.
- W3132912598 hasLocation W31329125981 @default.
- W3132912598 hasOpenAccess W3132912598 @default.
- W3132912598 hasPrimaryLocation W31329125981 @default.
- W3132912598 hasRelatedWork W1888163363 @default.
- W3132912598 hasRelatedWork W1999386415 @default.
- W3132912598 hasRelatedWork W2006693319 @default.
- W3132912598 hasRelatedWork W2007190608 @default.
- W3132912598 hasRelatedWork W2022849239 @default.
- W3132912598 hasRelatedWork W2154071769 @default.
- W3132912598 hasRelatedWork W2328524870 @default.
- W3132912598 hasRelatedWork W2725461327 @default.
- W3132912598 hasRelatedWork W2950765896 @default.
- W3132912598 hasRelatedWork W3132912598 @default.
- W3132912598 hasVolume "201" @default.
- W3132912598 isParatext "false" @default.
- W3132912598 isRetracted "false" @default.
- W3132912598 magId "3132912598" @default.
- W3132912598 workType "article" @default.