Matches in SemOpenAlex for { <https://semopenalex.org/work/W3132994888> ?p ?o ?g. }
- W3132994888 abstract "Although the discovery and characterization of multiple tumor antigens have sparked the development of many antigen/derived cancer vaccines, many are poorly immunogenic and thus, lack clinical efficacy. Adjuvants are therefore incorporated into vaccine formulations to trigger strong and long-lasting immune responses. Adjuvants have generally been classified into two categories: those that ‘depot’ antigens (e.g. mineral salts such as aluminum hydroxide, emulsions, liposomes) and those that act as immunostimulants (Toll Like Receptor agonists, saponins, cytokines). In addition, several novel technologies using vector-based delivery of antigens have been used. Unfortunately, the immune system declines with age, a phenomenon known as immunosenescence, and this is characterized by functional changes in both innate and adaptive cellular immunity systems as well as in lymph node architecture. While many of the immune functions decline over time, others paradoxically increase. Indeed, aging is known to be associated with a low level of chronic inflammation—inflamm-aging. Given that the median age of cancer diagnosis is 66 years and that immunotherapeutic interventions such as cancer vaccines are currently given in combination with or after other forms of treatments which themselves have immune-modulating potential such as surgery, chemotherapy and radiotherapy, the choice of adjuvants requires careful consideration in order to achieve the maximum immune response in a compromised environment. In addition, more clinical trials need to be performed to carefully assess how less conventional form of immune adjuvants, such as exercise, diet and psychological care which have all be shown to influence immune responses can be incorporated to improve the efficacy of cancer vaccines. In this review, adjuvants will be discussed with respect to the above-mentioned important elements." @default.
- W3132994888 created "2021-03-01" @default.
- W3132994888 creator A5010389468 @default.
- W3132994888 creator A5013902226 @default.
- W3132994888 creator A5020151936 @default.
- W3132994888 creator A5057129908 @default.
- W3132994888 creator A5063564476 @default.
- W3132994888 creator A5073567520 @default.
- W3132994888 date "2021-02-17" @default.
- W3132994888 modified "2023-10-11" @default.
- W3132994888 title "Cancer Vaccines: Adjuvant Potency, Importance of Age, Lifestyle, and Treatments" @default.
- W3132994888 cites W1037378468 @default.
- W3132994888 cites W1488583473 @default.
- W3132994888 cites W1512178367 @default.
- W3132994888 cites W1536264784 @default.
- W3132994888 cites W1570824425 @default.
- W3132994888 cites W1572827793 @default.
- W3132994888 cites W1573590923 @default.
- W3132994888 cites W1594981111 @default.
- W3132994888 cites W1602732985 @default.
- W3132994888 cites W1702502468 @default.
- W3132994888 cites W1703147773 @default.
- W3132994888 cites W1770811198 @default.
- W3132994888 cites W1798864970 @default.
- W3132994888 cites W1924252729 @default.
- W3132994888 cites W1926141441 @default.
- W3132994888 cites W1934784153 @default.
- W3132994888 cites W1950448919 @default.
- W3132994888 cites W1965174032 @default.
- W3132994888 cites W1965696083 @default.
- W3132994888 cites W1967361213 @default.
- W3132994888 cites W1968658765 @default.
- W3132994888 cites W1969516914 @default.
- W3132994888 cites W1970160028 @default.
- W3132994888 cites W1971416592 @default.
- W3132994888 cites W1971821333 @default.
- W3132994888 cites W1972141585 @default.
- W3132994888 cites W1973091654 @default.
- W3132994888 cites W1974541550 @default.
- W3132994888 cites W1975300031 @default.
- W3132994888 cites W1975679096 @default.
- W3132994888 cites W1975933747 @default.
- W3132994888 cites W1977016792 @default.
- W3132994888 cites W1977825672 @default.
- W3132994888 cites W1978480169 @default.
- W3132994888 cites W1978607297 @default.
- W3132994888 cites W1978615881 @default.
- W3132994888 cites W1979991507 @default.
- W3132994888 cites W1983064582 @default.
- W3132994888 cites W1986766802 @default.
- W3132994888 cites W1988102572 @default.
- W3132994888 cites W1990040323 @default.
- W3132994888 cites W1991148746 @default.
- W3132994888 cites W1992699637 @default.
- W3132994888 cites W1993169857 @default.
- W3132994888 cites W1993682245 @default.
- W3132994888 cites W1998591071 @default.
- W3132994888 cites W1999220701 @default.
- W3132994888 cites W2000708671 @default.
- W3132994888 cites W2002432836 @default.
- W3132994888 cites W2003138081 @default.
- W3132994888 cites W2003614266 @default.
- W3132994888 cites W2003807404 @default.
- W3132994888 cites W2004791006 @default.
- W3132994888 cites W2005068285 @default.
- W3132994888 cites W2006366843 @default.
- W3132994888 cites W2009048972 @default.
- W3132994888 cites W2009942296 @default.
- W3132994888 cites W2013469022 @default.
- W3132994888 cites W2013492504 @default.
- W3132994888 cites W2014985358 @default.
- W3132994888 cites W2015163231 @default.
- W3132994888 cites W2015544847 @default.
- W3132994888 cites W2016063463 @default.
- W3132994888 cites W2016612145 @default.
- W3132994888 cites W2023359997 @default.
- W3132994888 cites W2025421597 @default.
- W3132994888 cites W2025629271 @default.
- W3132994888 cites W2026359419 @default.
- W3132994888 cites W2028580603 @default.
- W3132994888 cites W2030132644 @default.
- W3132994888 cites W2032986193 @default.
- W3132994888 cites W2034028219 @default.
- W3132994888 cites W2035279182 @default.
- W3132994888 cites W2035697740 @default.
- W3132994888 cites W2035729149 @default.
- W3132994888 cites W2036159305 @default.
- W3132994888 cites W2036468894 @default.
- W3132994888 cites W2036961863 @default.
- W3132994888 cites W2038325530 @default.
- W3132994888 cites W2038632547 @default.
- W3132994888 cites W2038820219 @default.
- W3132994888 cites W2040013106 @default.
- W3132994888 cites W2043871309 @default.
- W3132994888 cites W2045814042 @default.
- W3132994888 cites W2047872172 @default.
- W3132994888 cites W2048771309 @default.
- W3132994888 cites W2048800818 @default.
- W3132994888 cites W2049126022 @default.
- W3132994888 cites W2050417053 @default.