FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133032319> ?p ?o ?g. }

• W3133032319 endingPage "238" @default.
• W3133032319 startingPage "238" @default.
• W3133032319 abstract "Background: Damage to axonal cells releases neurofilament light chain (NFL) into the cerebrospinal fluid and plasma. The objective of this study was to investigate NFL as a potential biomarker of disease activity in neurosarcoidosis. MRIs were graded according to enhancing lesions at different central nervous system (CNS) sites. Results: In cerebrospinal fluid, levels of NFL were higher in neurosarcoidosis patients (n = 20) median 2304 pg/mL (interquartile range (IQR) 630–19,612) compared to 426 pg/mL (IQR 261-571) in extra-neurologic sarcoidosis patients (n = 20) and 336 pg/mL (IQR 194–402) in healthy controls (n = 11) (p = 0.0002). In plasma, levels of NFL were higher in neurosarcoidosis patients median 28.2 pg/mL (IQR 11.5–49.3) compared to 6.2 pg/mL (IQR 4.3–8.2) in extra-neurologic sarcoidosis patients and 7.1 pg/mL (IQR 6.2–9.0) in healthy controls (p = 0.0001). Levels in both cerebrospinal fluid and plasma were higher in neurosarcoidosis patients with moderate/severe enhancement than patients with mild enhancement on MRI (p = 0.009 and p = 0.005, respectively). To distinguish neurosarcoidosis patients from extra-neurologic patients and healthy controls, a cut-off level of 630 pg/mL in cerebrospinal fluid had 94% specificity and 79% sensitivity, while a cut-off level of 11.4 pg/mL in plasma had 97% specificity and 75% sensitivity. Conclusions: NFL levels in cerebrospinal fluid and plasma are significantly higher in neurosarcoidosis patients compared to extra-neurologic patients and healthy controls, and the levels correlate to the extent of inflammation on MRI." @default.
• W3133032319 created "2021-03-01" @default.
• W3133032319 creator A5005931904 @default.
• W3133032319 creator A5022322491 @default.
• W3133032319 creator A5024861911 @default.
• W3133032319 creator A5034395246 @default.
• W3133032319 creator A5035578447 @default.
• W3133032319 creator A5043450072 @default.
• W3133032319 creator A5044397834 @default.
• W3133032319 creator A5047216506 @default.
• W3133032319 creator A5066965222 @default.
• W3133032319 creator A5078984917 @default.
• W3133032319 date "2021-02-14" @default.
• W3133032319 modified "2023-10-06" @default.
• W3133032319 title "Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis" @default.
• W3133032319 cites W1515996753 @default.
• W3133032319 cites W1978525597 @default.
• W3133032319 cites W1993830805 @default.
• W3133032319 cites W2074925134 @default.
• W3133032319 cites W2094338449 @default.
• W3133032319 cites W2157203036 @default.
• W3133032319 cites W2324996341 @default.
• W3133032319 cites W2614808368 @default.
• W3133032319 cites W2798236352 @default.
• W3133032319 cites W2806791998 @default.
• W3133032319 cites W2809158935 @default.
• W3133032319 cites W2889223700 @default.
• W3133032319 cites W2906249856 @default.
• W3133032319 cites W2939789416 @default.
• W3133032319 cites W2942436433 @default.
• W3133032319 cites W2970676275 @default.
• W3133032319 cites W2994840595 @default.
• W3133032319 cites W3004767455 @default.
• W3133032319 cites W3022627762 @default.
• W3133032319 cites W3022809997 @default.
• W3133032319 cites W3094509839 @default.
• W3133032319 cites W3097390375 @default.
• W3133032319 doi "https://doi.org/10.3390/brainsci11020238" @default.
• W3133032319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7918492" @default.
• W3133032319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33672795" @default.
• W3133032319 hasPublicationYear "2021" @default.
• W3133032319 type Work @default.
• W3133032319 sameAs 3133032319 @default.
• W3133032319 citedByCount "6" @default.
• W3133032319 countsByYear W31330323192021 @default.
• W3133032319 countsByYear W31330323192022 @default.
• W3133032319 countsByYear W31330323192023 @default.
• W3133032319 crossrefType "journal-article" @default.
• W3133032319 hasAuthorship W3133032319A5005931904 @default.
• W3133032319 hasAuthorship W3133032319A5022322491 @default.
• W3133032319 hasAuthorship W3133032319A5024861911 @default.
• W3133032319 hasAuthorship W3133032319A5034395246 @default.
• W3133032319 hasAuthorship W3133032319A5035578447 @default.
• W3133032319 hasAuthorship W3133032319A5043450072 @default.
• W3133032319 hasAuthorship W3133032319A5044397834 @default.
• W3133032319 hasAuthorship W3133032319A5047216506 @default.
• W3133032319 hasAuthorship W3133032319A5066965222 @default.
• W3133032319 hasAuthorship W3133032319A5078984917 @default.
• W3133032319 hasBestOaLocation W31330323191 @default.
• W3133032319 hasConcept C119060515 @default.
• W3133032319 hasConcept C126322002 @default.
• W3133032319 hasConcept C126838900 @default.
• W3133032319 hasConcept C142724271 @default.
• W3133032319 hasConcept C143409427 @default.
• W3133032319 hasConcept C185592680 @default.
• W3133032319 hasConcept C2778335692 @default.
• W3133032319 hasConcept C2779651940 @default.
• W3133032319 hasConcept C2781197716 @default.
• W3133032319 hasConcept C2781301800 @default.
• W3133032319 hasConcept C55493867 @default.
• W3133032319 hasConcept C71924100 @default.
• W3133032319 hasConcept C90924648 @default.
• W3133032319 hasConceptScore W3133032319C119060515 @default.
• W3133032319 hasConceptScore W3133032319C126322002 @default.
• W3133032319 hasConceptScore W3133032319C126838900 @default.
• W3133032319 hasConceptScore W3133032319C142724271 @default.
• W3133032319 hasConceptScore W3133032319C143409427 @default.
• W3133032319 hasConceptScore W3133032319C185592680 @default.
• W3133032319 hasConceptScore W3133032319C2778335692 @default.
• W3133032319 hasConceptScore W3133032319C2779651940 @default.
• W3133032319 hasConceptScore W3133032319C2781197716 @default.
• W3133032319 hasConceptScore W3133032319C2781301800 @default.
• W3133032319 hasConceptScore W3133032319C55493867 @default.
• W3133032319 hasConceptScore W3133032319C71924100 @default.
• W3133032319 hasConceptScore W3133032319C90924648 @default.
• W3133032319 hasIssue "2" @default.
• W3133032319 hasLocation W31330323191 @default.
• W3133032319 hasLocation W31330323192 @default.
• W3133032319 hasLocation W31330323193 @default.
• W3133032319 hasLocation W31330323194 @default.
• W3133032319 hasOpenAccess W3133032319 @default.
• W3133032319 hasPrimaryLocation W31330323191 @default.
• W3133032319 hasRelatedWork W1499911817 @default.
• W3133032319 hasRelatedWork W1505874735 @default.
• W3133032319 hasRelatedWork W2095932214 @default.
• W3133032319 hasRelatedWork W2162852067 @default.
• W3133032319 hasRelatedWork W2399595455 @default.
• W3133032319 hasRelatedWork W2407714927 @default.

• next