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- W3133085887 abstract "The exquisite structure-function correlations observed in filamentous protein assemblies provide a paradigm for the creation of synthetic peptide-based nanomaterials. However, the plasticity of quaternary structure in sequence-space and the lability of helical symmetry present significant challenges to the de novo design and structural analysis of such filaments. Here, we describe a rational approach to design self-assembling peptide nanotubes based on controlling lateral interactions between protofilaments having an unusual cross-α supramolecular architecture. Near-atomic resolution cryo-EM structural analysis of seven designed nanotubes provides insight into the designability of interfaces within these synthetic peptide assemblies and identifies a non-native structural interaction based on a pair of arginine residues. This arginine clasp motif can robustly mediate cohesive interactions between protofilaments within these cross-α nanotubes. The structure of these resultant assemblies can be controlled through the sequence and length of the peptide subunits, which generates synthetic peptide filaments of similar dimensions to native protein filaments such as flagella and pili." @default.
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- W3133085887 date "2021-02-01" @default.
- W3133085887 modified "2023-09-27" @default.
- W3133085887 title "Cross α-Helical Nanotubes: Mining the Designability Landscape for Filamentous Peptide Nanomaterials" @default.
- W3133085887 doi "https://doi.org/10.1016/j.bpj.2020.11.1226" @default.
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