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- W3133109028 abstract "Although cumulative genetic and epigenetic changes in cancer cells are correlated with tumor malignancy, accumulating evidence supports that tumor cell-extrinsic mechanisms play an essential role in driving tumor progression. The tissue architecture surrounding tumor cells evolves during disease progression and becomes a significant barrier to cancer treatments. The functional traits of the tumor microenvironment (TME), either tumor suppressive or supportive, are defined by the distribution of various stromal cells and their sequential and reciprocal cellular interactions. Recent studies have uncovered a significant heterogeneity in stromal cells and identified specific subpopulations correlated with clinical outcomes, providing novel insights into the complex TME system that drives tumor progression and therapy resistance. Moreover, a small population of tumor cells with tumor-initiating and drug-resistant capabilities, cancer stem cells (CSCs), is maintained by the specialized TME, the so-called CSC niche. The crosstalk between CSCs and niche cells is an attractive avenue for identifying the vulnerability of difficult-to-treat cancers. Here, we review the recent advance in understanding TME biology and its impact on CSCs. We then focus on a newly identified niche signaling loop by which CSCs promote malignant progression and drug resistance of squamous cell carcinoma. The CSC niche is a promising research field that needs more attention and could facilitate the development of durable cancer treatment. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
- W3133109028 created "2021-03-01" @default.
- W3133109028 creator A5020939010 @default.
- W3133109028 creator A5034430377 @default.
- W3133109028 creator A5086624691 @default.
- W3133109028 date "2021-03-18" @default.
- W3133109028 modified "2023-10-10" @default.
- W3133109028 title "An emerging role for cellular crosstalk in the cancer stem cell niche" @default.
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- W3133109028 doi "https://doi.org/10.1002/path.5655" @default.
- W3133109028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33634866" @default.
- W3133109028 hasPublicationYear "2021" @default.