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- W3133166882 endingPage "102023" @default.
- W3133166882 startingPage "102023" @default.
- W3133166882 abstract "Temporarily storing a list of items in working memory (WM), a fundamental ability in cognition, has been posited to rely on the temporal dynamics of multi-item neural representations during retention. However, the causal evidence, particularly in human subjects, is still lacking, let alone WM manipulation. Here, we develop a novel dynamic perturbation approach to manipulate the relative memory strength of WM items held in human brain, by presenting temporally correlated luminance sequences during retention to interfere with the multi-item neural dynamics. Six experiments on more than 150 subjects confirm the effectiveness of this WM manipulation approach. A computational model combining continuous attractor neural network (CANN) and short-term synaptic plasticity (STP) principles further reproduces all the empirical findings. The model reveals that the dynamic perturbation modifies the synaptic efficacies of WM items through STP principles, eventually leading to changes in their relative memory strengths. Our results support the causal role of temporal dynamics of neural network in mediating multi-item WM, and offer a promising, purely bottom-up approach to manipulate WM." @default.
- W3133166882 created "2021-03-01" @default.
- W3133166882 creator A5005244980 @default.
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- W3133166882 creator A5026410403 @default.
- W3133166882 creator A5066096859 @default.
- W3133166882 creator A5079631942 @default.
- W3133166882 date "2021-06-01" @default.
- W3133166882 modified "2023-10-18" @default.
- W3133166882 title "Temporally coherent perturbation of neural dynamics during retention alters human multi-item working memory" @default.
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- W3133166882 doi "https://doi.org/10.1016/j.pneurobio.2021.102023" @default.
- W3133166882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33617918" @default.
- W3133166882 hasPublicationYear "2021" @default.
- W3133166882 type Work @default.