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- W3133181271 abstract "A series of new 1,3,4-thiadiazines were synthesized by the conventional method of dehydroacetic acid, thiocarbohydrazide and substituted phenacyl bromides or substituted 3-(2-bromoacetyl) coumarins. Structures of all the synthesized compounds were confirmed by spectral (1H &13C NMR, FTIR, Mass) and analytical data. The target compounds were screened for their in vitro anticancer activity, From the in vitro anticancer results, it was found that the compound 6a has shown significant activity with the standard. Furthermore, the synthesized 1,3,4-thiadiazines were inflicted to molecular docking simulations for gaining insights into their mechanism of action and possible mode of binding against STAT3. The docking results were consistent with the experimental data." @default.
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- W3133181271 date "2021-06-01" @default.
- W3133181271 modified "2023-09-25" @default.
- W3133181271 title "A facile one-pot, three component synthesis of a new series of 1,3,4-thiadiazines: Anticancer evaluation and molecular docking studies" @default.
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- W3133181271 doi "https://doi.org/10.1016/j.molstruc.2021.130111" @default.
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