Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133230810> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3133230810 endingPage "e327" @default.
- W3133230810 startingPage "e320" @default.
- W3133230810 abstract "Immune thrombocytopenia (ITP) is characterized by dysregulated cellular immunity. Interleukin 17 (IL-17) and its secreting cells (Th17) are involved in the pathogenesis of ITP. Retinoic acid receptor–related orphan receptor γt (RORγt) is the chief regulator of Th17 development. The interaction among Runt-related transcription factor 1 (RUNX1) and IL-17-related genes in ITP remains questionable. The study aimed to evaluate the expression of RUNX1 and RORγt together with IL-17A and IL-17F genes in childhood ITP to investigate their contribution to disease pathogenesis and clinical presentation. Ninety children were included, 30 primary active ITP patients, 30 ITP patients in remission after treatment, and 30 healthy controls. The expression levels of RUNX1 , RORγt , IL-17A , and IL-17F genes were measured. Significant overexpression of RUNX1 , RORγt , IL-17A , and IL-17F genes was observed in active ITP patients, which was restored to normal levels in both ITP patients in remission and controls ( P <0.001 for the 4 genes). Positive correlations between RUNX1 , RORγt , IL-17A , and IL-17F expression levels were observed in active ITP patients ( P =0.001 for RUNX1 with RORγt , P <0.001 for RUNX1 with both IL-17A and IL-17F , regarding RORγt P <0.001 with IL-17A and P =0.002 with IL-17F , P =0.001 for IL-17A with IL-17F ). In conclusion, RUNX1 is possibly involved in the molecular pathogenesis of ITP upregulating the expression of Th17-secreted cytokines, IL-17A and IL-17F , through RORγt at the transcriptional level. Thus, targeting RUNX1 or RORγt may be new alternative therapeutic strategies." @default.
- W3133230810 created "2021-03-01" @default.
- W3133230810 creator A5014629637 @default.
- W3133230810 creator A5066130194 @default.
- W3133230810 creator A5081292112 @default.
- W3133230810 date "2021-02-25" @default.
- W3133230810 modified "2023-09-26" @default.
- W3133230810 title "Increased Expression of IL-17A and IL-17F Is Correlated With RUNX1 and RORγT in Pediatric Patients With Primary Immune Thrombocytopenia" @default.
- W3133230810 cites W1522941314 @default.
- W3133230810 cites W1832173750 @default.
- W3133230810 cites W1984073642 @default.
- W3133230810 cites W1989182431 @default.
- W3133230810 cites W2009609863 @default.
- W3133230810 cites W2035979892 @default.
- W3133230810 cites W2058436765 @default.
- W3133230810 cites W2059158081 @default.
- W3133230810 cites W2068180510 @default.
- W3133230810 cites W2069923423 @default.
- W3133230810 cites W2071409203 @default.
- W3133230810 cites W2096447848 @default.
- W3133230810 cites W2097591338 @default.
- W3133230810 cites W2107277218 @default.
- W3133230810 cites W2117357357 @default.
- W3133230810 cites W2142017607 @default.
- W3133230810 cites W2154728251 @default.
- W3133230810 cites W2169126804 @default.
- W3133230810 cites W2314461317 @default.
- W3133230810 cites W2409142105 @default.
- W3133230810 cites W2590668924 @default.
- W3133230810 cites W2799786040 @default.
- W3133230810 doi "https://doi.org/10.1097/mph.0000000000002108" @default.
- W3133230810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33633027" @default.
- W3133230810 hasPublicationYear "2021" @default.
- W3133230810 type Work @default.
- W3133230810 sameAs 3133230810 @default.
- W3133230810 citedByCount "3" @default.
- W3133230810 countsByYear W31332308102022 @default.
- W3133230810 countsByYear W31332308102023 @default.
- W3133230810 crossrefType "journal-article" @default.
- W3133230810 hasAuthorship W3133230810A5014629637 @default.
- W3133230810 hasAuthorship W3133230810A5066130194 @default.
- W3133230810 hasAuthorship W3133230810A5081292112 @default.
- W3133230810 hasConcept C104317684 @default.
- W3133230810 hasConcept C126322002 @default.
- W3133230810 hasConcept C203014093 @default.
- W3133230810 hasConcept C2778193527 @default.
- W3133230810 hasConcept C2778690821 @default.
- W3133230810 hasConcept C2779161069 @default.
- W3133230810 hasConcept C2779727006 @default.
- W3133230810 hasConcept C2780942790 @default.
- W3133230810 hasConcept C2781121885 @default.
- W3133230810 hasConcept C47348012 @default.
- W3133230810 hasConcept C54355233 @default.
- W3133230810 hasConcept C71924100 @default.
- W3133230810 hasConcept C74172505 @default.
- W3133230810 hasConcept C74737994 @default.
- W3133230810 hasConcept C86339819 @default.
- W3133230810 hasConcept C86803240 @default.
- W3133230810 hasConcept C8891405 @default.
- W3133230810 hasConceptScore W3133230810C104317684 @default.
- W3133230810 hasConceptScore W3133230810C126322002 @default.
- W3133230810 hasConceptScore W3133230810C203014093 @default.
- W3133230810 hasConceptScore W3133230810C2778193527 @default.
- W3133230810 hasConceptScore W3133230810C2778690821 @default.
- W3133230810 hasConceptScore W3133230810C2779161069 @default.
- W3133230810 hasConceptScore W3133230810C2779727006 @default.
- W3133230810 hasConceptScore W3133230810C2780942790 @default.
- W3133230810 hasConceptScore W3133230810C2781121885 @default.
- W3133230810 hasConceptScore W3133230810C47348012 @default.
- W3133230810 hasConceptScore W3133230810C54355233 @default.
- W3133230810 hasConceptScore W3133230810C71924100 @default.
- W3133230810 hasConceptScore W3133230810C74172505 @default.
- W3133230810 hasConceptScore W3133230810C74737994 @default.
- W3133230810 hasConceptScore W3133230810C86339819 @default.
- W3133230810 hasConceptScore W3133230810C86803240 @default.
- W3133230810 hasConceptScore W3133230810C8891405 @default.
- W3133230810 hasIssue "3" @default.
- W3133230810 hasLocation W31332308101 @default.
- W3133230810 hasOpenAccess W3133230810 @default.
- W3133230810 hasPrimaryLocation W31332308101 @default.
- W3133230810 hasRelatedWork W2114315521 @default.
- W3133230810 hasRelatedWork W2154728251 @default.
- W3133230810 hasRelatedWork W2212679432 @default.
- W3133230810 hasRelatedWork W2350475825 @default.
- W3133230810 hasRelatedWork W2368424105 @default.
- W3133230810 hasRelatedWork W2994939569 @default.
- W3133230810 hasRelatedWork W3032599061 @default.
- W3133230810 hasRelatedWork W3120210947 @default.
- W3133230810 hasRelatedWork W3133230810 @default.
- W3133230810 hasRelatedWork W3194847506 @default.
- W3133230810 hasVolume "43" @default.
- W3133230810 isParatext "false" @default.
- W3133230810 isRetracted "false" @default.
- W3133230810 magId "3133230810" @default.
- W3133230810 workType "article" @default.