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- W3133268630 abstract "Class A G protein-coupled receptors (GPCRs) have been reported to form receptor heteromers and serve as allosteric regulators of one another, yet their existence has become a highly contested topic. In this project, we employ a minimally invasive approach of introducing unnatural amino acids (UAAs), using amber codon suppression, at strategic positions predicted to form the heteromeric interface of the dopamine 2 (D2) and serotonin 5HT2A (2A) receptor (R) heteromer that is implicated in schizophrenia." @default.
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- W3133268630 date "2021-02-01" @default.
- W3133268630 modified "2023-09-30" @default.
- W3133268630 title "Photoaffinity Labeled Unnatural Amino Acid Crosslinking Stabilizes a Trans-Signaling Conformation between the D2-5HT2A Receptor Heteromer" @default.
- W3133268630 doi "https://doi.org/10.1016/j.bpj.2020.11.2062" @default.
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