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• W3133298198 abstract "The long-chain noncoding RNA ADAMTS9-AS2 functions as a tumor suppressor gene in many cancers. However, the underlying mechanism remains to be fully elucidated in bladder cancer (BC). ADAMTS9-AS2 exhibited a lower expression level in BC samples and cell lines. In addition, overexpression of ADAMTS9-AS2 obviously suppressed proliferation and migration, and induced apoptosis of T24 cells, while transfection with the ADAMTS9-AS2 inhibitor had opposite results in 5637 cells. Furthermore, miR-182-5p was the target microRNA of ADAMTS9-AS2 and was negatively correlated with ADAMTS9-AS2 expression. Upregulation of miR-182-5p reversed the effects of ADAMTS9-AS2 overexpression on biological function in T24 cells. ADAMTS9-AS2 was a tumor suppressor that inhibited BC cell proliferation and induced cellular apoptosis by targeting miR-182-5p, and it could be a promising target for BC treatment." @default.
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• W3133298198 date "2021-02-01" @default.
• W3133298198 modified "2023-10-01" @default.
• W3133298198 title "Long-Chain Noncoding RNA ADAMTS9-AS2 Regulates Proliferation, Migration, and Apoptosis in Bladder Cancer Cells Through Regulating miR-182-5p" @default.
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• W3133298198 doi "https://doi.org/10.1089/jir.2020.0137" @default.
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