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• W3133370877 abstract "Mitochondria contain an autonomous and spatially segregated genome. The organizational unit of their genome is the nucleoid, which consists of mitochondrial DNA (mtDNA) and associated architectural proteins. Here, we show that phase separation is the primary physical mechanism for assembly and size control of the mitochondrial nucleoid (mt-nucleoid). The major mtDNA-binding protein TFAM spontaneously phase separates in vitro via weak, multivalent interactions into droplets with slow internal dynamics. TFAM and mtDNA form heterogenous, viscoelastic structures in vitro, which recapitulate the dynamics and behavior of mt-nucleoids in vivo. Mt-nucleoids coalesce into larger droplets in response to various forms of cellular stress, as evidenced by the enlarged and transcriptionally active nucleoids in mitochondria from patients with the premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS). Our results point to phase separation as an evolutionarily conserved mechanism of genome organization." @default.
• W3133370877 created "2021-03-01" @default.
• W3133370877 creator A5003426490 @default.
• W3133370877 creator A5017796398 @default.
• W3133370877 creator A5025612566 @default.
• W3133370877 creator A5033590861 @default.
• W3133370877 creator A5087966982 @default.
• W3133370877 creator A5089917586 @default.
• W3133370877 date "2021-02-23" @default.
• W3133370877 modified "2023-10-15" @default.
• W3133370877 title "Self‐assembly of multi‐component mitochondrial nucleoids via phase separation" @default.
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