Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133375013> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3133375013 abstract "Although eukaryotic messenger RNAs (mRNAs) normally possess a 5’ end N7-methyl guanosine (m7G) cap, a non-canonical 5’ nicotinamide adenine dinucleotide (NAD+) cap can tag certain transcripts for degradation mediated by the NAD+ decapping enzyme DXO1. Despite its importance as a post-transcriptional regulator, whether NAD+ capping dynamically responds to specific stimuli to regulate eukaryotic transcriptomes remains unknown. Here, we reveal that NAD+ capping is a widespread and tissue-specific mechanism to regulate mRNA stability. In the absence of DXO1 function, NAD+ capped transcripts are instead degraded via a RNA-DEPENDENT RNA POLYMERASE 6-mediated small RNA biogenesis mechanism to permit recycling of the trapped NAD+ molecules. Remarkably, the NAD+ capped transcriptome is significantly remodeled in response to the essential plant hormone abscisic acid in a mechanism that is primarily independent of DXO1. Overall, our findings reveal a previously uncharacterized and essential role of NAD+ capping in dynamically regulating transcript stability during specific physiological responses." @default.
- W3133375013 created "2021-03-01" @default.
- W3133375013 creator A5017064013 @default.
- W3133375013 creator A5017848789 @default.
- W3133375013 creator A5021120553 @default.
- W3133375013 creator A5027736631 @default.
- W3133375013 creator A5044070022 @default.
- W3133375013 creator A5044562528 @default.
- W3133375013 creator A5068779075 @default.
- W3133375013 creator A5074995290 @default.
- W3133375013 creator A5082741046 @default.
- W3133375013 creator A5086173555 @default.
- W3133375013 date "2020-01-01" @default.
- W3133375013 modified "2023-09-23" @default.
- W3133375013 title "Messenger RNA 5’ NAD+ Capping is a Dynamic Regulatory Epitranscriptome Mark that is Required for Proper Response to Abscisic Acid in Arabidopsis" @default.
- W3133375013 doi "https://doi.org/10.2139/ssrn.3614129" @default.
- W3133375013 hasPublicationYear "2020" @default.
- W3133375013 type Work @default.
- W3133375013 sameAs 3133375013 @default.
- W3133375013 citedByCount "1" @default.
- W3133375013 countsByYear W31333750132021 @default.
- W3133375013 crossrefType "journal-article" @default.
- W3133375013 hasAuthorship W3133375013A5017064013 @default.
- W3133375013 hasAuthorship W3133375013A5017848789 @default.
- W3133375013 hasAuthorship W3133375013A5021120553 @default.
- W3133375013 hasAuthorship W3133375013A5027736631 @default.
- W3133375013 hasAuthorship W3133375013A5044070022 @default.
- W3133375013 hasAuthorship W3133375013A5044562528 @default.
- W3133375013 hasAuthorship W3133375013A5068779075 @default.
- W3133375013 hasAuthorship W3133375013A5074995290 @default.
- W3133375013 hasAuthorship W3133375013A5082741046 @default.
- W3133375013 hasAuthorship W3133375013A5086173555 @default.
- W3133375013 hasConcept C104317684 @default.
- W3133375013 hasConcept C105580179 @default.
- W3133375013 hasConcept C181199279 @default.
- W3133375013 hasConcept C185592680 @default.
- W3133375013 hasConcept C2776901170 @default.
- W3133375013 hasConcept C2779591172 @default.
- W3133375013 hasConcept C55493867 @default.
- W3133375013 hasConcept C67705224 @default.
- W3133375013 hasConcept C75520062 @default.
- W3133375013 hasConcept C86803240 @default.
- W3133375013 hasConcept C95444343 @default.
- W3133375013 hasConceptScore W3133375013C104317684 @default.
- W3133375013 hasConceptScore W3133375013C105580179 @default.
- W3133375013 hasConceptScore W3133375013C181199279 @default.
- W3133375013 hasConceptScore W3133375013C185592680 @default.
- W3133375013 hasConceptScore W3133375013C2776901170 @default.
- W3133375013 hasConceptScore W3133375013C2779591172 @default.
- W3133375013 hasConceptScore W3133375013C55493867 @default.
- W3133375013 hasConceptScore W3133375013C67705224 @default.
- W3133375013 hasConceptScore W3133375013C75520062 @default.
- W3133375013 hasConceptScore W3133375013C86803240 @default.
- W3133375013 hasConceptScore W3133375013C95444343 @default.
- W3133375013 hasLocation W31333750131 @default.
- W3133375013 hasOpenAccess W3133375013 @default.
- W3133375013 hasPrimaryLocation W31333750131 @default.
- W3133375013 hasRelatedWork W16070094 @default.
- W3133375013 hasRelatedWork W1857 @default.
- W3133375013 hasRelatedWork W20418751 @default.
- W3133375013 hasRelatedWork W20718919 @default.
- W3133375013 hasRelatedWork W23613709 @default.
- W3133375013 hasRelatedWork W27361888 @default.
- W3133375013 hasRelatedWork W34449884 @default.
- W3133375013 hasRelatedWork W34926440 @default.
- W3133375013 hasRelatedWork W39064870 @default.
- W3133375013 hasRelatedWork W5184053 @default.
- W3133375013 isParatext "false" @default.
- W3133375013 isRetracted "false" @default.
- W3133375013 magId "3133375013" @default.
- W3133375013 workType "article" @default.