Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133393695> ?p ?o ?g. }
- W3133393695 endingPage "122220" @default.
- W3133393695 startingPage "122220" @default.
- W3133393695 abstract "Tumor is a kind of abnormal organism generated by the proliferation and differentiation of cells in the body under the action of various initiating and promoting factors, which seriously threatens human life and health. Tumorigenesis is a gradual process that involves multistage reactions and the accumulation of mutations. Gene mutation usually occurs during tumorigenesis, and can be used for tumor diagnosis. Early diagnosis is the most effective way to improve the cure rate and reduce the mortality rate. Among the peripheral blood circulating tumor DNA (ctDNA), gene mutation in keeping with tumor cells can be detected, which can potentially replace tumor tissue section for early diagnosis. It has been considered as a liquid biopsy marker with good clinical application prospect. However, the high fragmentation and low concentration of ctDNA in blood result in the difficulty of tumor stage determination. Therefore, high sensitive and specific mutation detection methods have been developed to detect trace mutant ctDNA. At present, the approaches include digital PCR (dPCR), Bead, Emulsion, Amplification and Magnetic (BEAMing), Next Generation Sequencing (NGS), Amplification Refractory Mutation System (ARMS), etc. In this paper, the principle, characteristics, latest progress and application prospects of these methods are reviewed, which will facilitate researchers to choose appropriate ctDNA detection approaches." @default.
- W3133393695 created "2021-03-01" @default.
- W3133393695 creator A5003980543 @default.
- W3133393695 creator A5041119480 @default.
- W3133393695 creator A5053683203 @default.
- W3133393695 creator A5077079392 @default.
- W3133393695 date "2021-06-01" @default.
- W3133393695 modified "2023-10-18" @default.
- W3133393695 title "Circulating tumor DNA analysis for tumor diagnosis" @default.
- W3133393695 cites W1518996791 @default.
- W3133393695 cites W1546843241 @default.
- W3133393695 cites W1794677843 @default.
- W3133393695 cites W1806975025 @default.
- W3133393695 cites W1978014995 @default.
- W3133393695 cites W1982758059 @default.
- W3133393695 cites W1983466841 @default.
- W3133393695 cites W1984960955 @default.
- W3133393695 cites W1990601349 @default.
- W3133393695 cites W1993861922 @default.
- W3133393695 cites W1998694827 @default.
- W3133393695 cites W2001657129 @default.
- W3133393695 cites W2005764143 @default.
- W3133393695 cites W2013412470 @default.
- W3133393695 cites W2030010732 @default.
- W3133393695 cites W2040928840 @default.
- W3133393695 cites W2044024547 @default.
- W3133393695 cites W2048513224 @default.
- W3133393695 cites W2052099831 @default.
- W3133393695 cites W2059796969 @default.
- W3133393695 cites W2064063117 @default.
- W3133393695 cites W2079345276 @default.
- W3133393695 cites W2082063053 @default.
- W3133393695 cites W2088164932 @default.
- W3133393695 cites W2089135124 @default.
- W3133393695 cites W2089470652 @default.
- W3133393695 cites W2090806677 @default.
- W3133393695 cites W2091273808 @default.
- W3133393695 cites W2096837288 @default.
- W3133393695 cites W2107721849 @default.
- W3133393695 cites W2109061692 @default.
- W3133393695 cites W2117753040 @default.
- W3133393695 cites W2117906597 @default.
- W3133393695 cites W2120869188 @default.
- W3133393695 cites W2128114769 @default.
- W3133393695 cites W2130347047 @default.
- W3133393695 cites W2133986911 @default.
- W3133393695 cites W2138270253 @default.
- W3133393695 cites W2150294514 @default.
- W3133393695 cites W2153010521 @default.
- W3133393695 cites W2171237493 @default.
- W3133393695 cites W2175009659 @default.
- W3133393695 cites W2176620333 @default.
- W3133393695 cites W2179502834 @default.
- W3133393695 cites W2195049434 @default.
- W3133393695 cites W2223419060 @default.
- W3133393695 cites W2239118478 @default.
- W3133393695 cites W2258935349 @default.
- W3133393695 cites W2315794092 @default.
- W3133393695 cites W2326753855 @default.
- W3133393695 cites W2329906190 @default.
- W3133393695 cites W2401679235 @default.
- W3133393695 cites W2418515714 @default.
- W3133393695 cites W2436762547 @default.
- W3133393695 cites W2479773785 @default.
- W3133393695 cites W2481084813 @default.
- W3133393695 cites W2511420722 @default.
- W3133393695 cites W2561892851 @default.
- W3133393695 cites W2590954301 @default.
- W3133393695 cites W2596267403 @default.
- W3133393695 cites W2606375714 @default.
- W3133393695 cites W2608738563 @default.
- W3133393695 cites W2609390578 @default.
- W3133393695 cites W2616020718 @default.
- W3133393695 cites W2626230492 @default.
- W3133393695 cites W2730652839 @default.
- W3133393695 cites W2732121391 @default.
- W3133393695 cites W2737626698 @default.
- W3133393695 cites W2747391144 @default.
- W3133393695 cites W2752663582 @default.
- W3133393695 cites W2770491016 @default.
- W3133393695 cites W2772185738 @default.
- W3133393695 cites W2782502895 @default.
- W3133393695 cites W2786990528 @default.
- W3133393695 cites W2793825788 @default.
- W3133393695 cites W2796612692 @default.
- W3133393695 cites W2797445881 @default.
- W3133393695 cites W2798118575 @default.
- W3133393695 cites W2799694557 @default.
- W3133393695 cites W2805768122 @default.
- W3133393695 cites W2806156071 @default.
- W3133393695 cites W2808752358 @default.
- W3133393695 cites W2832813378 @default.
- W3133393695 cites W2888239683 @default.
- W3133393695 cites W2890369989 @default.
- W3133393695 cites W2897338863 @default.
- W3133393695 cites W2897399596 @default.
- W3133393695 cites W2899217787 @default.
- W3133393695 cites W2901167168 @default.