FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133446450> ?p ?o ?g. }

• W3133446450 abstract "Purpose: The aim of the present study was to determine whether de-escalation guided by blood cultures for patients with a diagnosis of sepsis, severe sepsis or septic shock reduces mortality, and antimicrobial drug resistance (ADR). Methods: A prospective, single-center, cohort study was conducted with adults admitted to the ICU with a diagnosis of sepsis, severe sepsis, or septic shock at a public hospital in Sorocaba, State of São Paulo, Brazil, from January 2013 to December 2013. We excluded patients who had negative blood cultures. Patients who had replaced the initial empirical broad-spectrum antibiotic therapy (EAT) by the antibiotic therapy guided by blood cultures were compared with those who continued receiving EAT. The outcome included mortality and antimicrobial drug resistance. We used the Cox regression (proportional hazards regression) and the Poisson regression to analyze the association between antibiotic therapy guided by blood cultures (ATGBC) and outcomes. The statistical adjustment in all models included the following variables: sex, age, APACHE II (Acute Physiology And Chronic Health Evaluation II) score and SOFA (Sequential Organ Failure Assessment) score. Results: Among the 686 patients who were admitted to the intensive care unit, 91 were included in this study. The mean age of the patients was 52.7 years (standard deviation = 18.5 years) and 70.3% were male. EAT was replaced by ATGBC in 33 patients (36.3%) while 58 patients (63.7%) continued receiving EAT. Overall hospital mortality decreased from 56.9% in patients who received EAT to 48.5% in patients who received ATGBC [Hazard ratio- HR 0.44 (95% CI 0.24–0.82), p = 0.009]. There was no association between ATGBC and ADR [HR 0.90 (95% CI 0.78 – 1.03) p = 0.15]. Conclusions: Although the early and appropriate empirical EAT is undoubtedly an important factor prognostic, ATGBC can reduce the mortality in these patients." @default.
• W3133446450 created "2021-03-01" @default.
• W3133446450 creator A5005095857 @default.
• W3133446450 creator A5014141569 @default.
• W3133446450 creator A5014551696 @default.
• W3133446450 creator A5026942372 @default.
• W3133446450 creator A5050921356 @default.
• W3133446450 creator A5063052268 @default.
• W3133446450 creator A5067164915 @default.
• W3133446450 creator A5072118875 @default.
• W3133446450 date "2021-02-12" @default.
• W3133446450 modified "2023-09-27" @default.
• W3133446450 title "Feasibility of De-Escalation Implementation for Positive Blood Cultures in Patients With Sepsis: A Prospective Cohort Study" @default.
• W3133446450 cites W1998302401 @default.
• W3133446450 cites W2019349925 @default.
• W3133446450 cites W2053430308 @default.
• W3133446450 cites W2054938569 @default.
• W3133446450 cites W2079215889 @default.
• W3133446450 cites W2087897655 @default.
• W3133446450 cites W2092802285 @default.
• W3133446450 cites W2095077206 @default.
• W3133446450 cites W2097758001 @default.
• W3133446450 cites W2119498007 @default.
• W3133446450 cites W2133935069 @default.
• W3133446450 cites W2139370844 @default.
• W3133446450 cites W2145577370 @default.
• W3133446450 cites W2253853790 @default.
• W3133446450 cites W2280404143 @default.
• W3133446450 cites W2313266166 @default.
• W3133446450 cites W2586708275 @default.
• W3133446450 cites W2745432684 @default.
• W3133446450 cites W2755519540 @default.
• W3133446450 cites W2768146862 @default.
• W3133446450 cites W2794985056 @default.
• W3133446450 cites W2796111069 @default.
• W3133446450 cites W2843416743 @default.
• W3133446450 cites W2900483646 @default.
• W3133446450 cites W2907121739 @default.
• W3133446450 cites W2956114633 @default.
• W3133446450 cites W2978805391 @default.
• W3133446450 cites W2994455367 @default.
• W3133446450 cites W2998853022 @default.
• W3133446450 cites W3005202652 @default.
• W3133446450 cites W3013265183 @default.
• W3133446450 cites W3017087303 @default.
• W3133446450 cites W3021217253 @default.
• W3133446450 cites W3023757607 @default.
• W3133446450 cites W3088776401 @default.
• W3133446450 cites W4294116629 @default.
• W3133446450 doi "https://doi.org/10.3389/fphar.2020.576849" @default.
• W3133446450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7907639" @default.
• W3133446450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33643032" @default.
• W3133446450 hasPublicationYear "2021" @default.
• W3133446450 type Work @default.
• W3133446450 sameAs 3133446450 @default.
• W3133446450 citedByCount "0" @default.
• W3133446450 crossrefType "journal-article" @default.
• W3133446450 hasAuthorship W3133446450A5005095857 @default.
• W3133446450 hasAuthorship W3133446450A5014141569 @default.
• W3133446450 hasAuthorship W3133446450A5014551696 @default.
• W3133446450 hasAuthorship W3133446450A5026942372 @default.
• W3133446450 hasAuthorship W3133446450A5050921356 @default.
• W3133446450 hasAuthorship W3133446450A5063052268 @default.
• W3133446450 hasAuthorship W3133446450A5067164915 @default.
• W3133446450 hasAuthorship W3133446450A5072118875 @default.
• W3133446450 hasBestOaLocation W31334464501 @default.
• W3133446450 hasConcept C126322002 @default.
• W3133446450 hasConcept C177713679 @default.
• W3133446450 hasConcept C188816634 @default.
• W3133446450 hasConcept C201903717 @default.
• W3133446450 hasConcept C207103383 @default.
• W3133446450 hasConcept C2776376669 @default.
• W3133446450 hasConcept C2777628635 @default.
• W3133446450 hasConcept C2778384902 @default.
• W3133446450 hasConcept C2779473907 @default.
• W3133446450 hasConcept C2908647359 @default.
• W3133446450 hasConcept C44249647 @default.
• W3133446450 hasConcept C501593827 @default.
• W3133446450 hasConcept C50382708 @default.
• W3133446450 hasConcept C71924100 @default.
• W3133446450 hasConcept C72563966 @default.
• W3133446450 hasConcept C73269764 @default.
• W3133446450 hasConcept C86803240 @default.
• W3133446450 hasConcept C89423630 @default.
• W3133446450 hasConcept C99454951 @default.
• W3133446450 hasConceptScore W3133446450C126322002 @default.
• W3133446450 hasConceptScore W3133446450C177713679 @default.
• W3133446450 hasConceptScore W3133446450C188816634 @default.
• W3133446450 hasConceptScore W3133446450C201903717 @default.
• W3133446450 hasConceptScore W3133446450C207103383 @default.
• W3133446450 hasConceptScore W3133446450C2776376669 @default.
• W3133446450 hasConceptScore W3133446450C2777628635 @default.
• W3133446450 hasConceptScore W3133446450C2778384902 @default.
• W3133446450 hasConceptScore W3133446450C2779473907 @default.
• W3133446450 hasConceptScore W3133446450C2908647359 @default.
• W3133446450 hasConceptScore W3133446450C44249647 @default.
• W3133446450 hasConceptScore W3133446450C501593827 @default.
• W3133446450 hasConceptScore W3133446450C50382708 @default.
• W3133446450 hasConceptScore W3133446450C71924100 @default.
• W3133446450 hasConceptScore W3133446450C72563966 @default.

• next