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- W3133490592 endingPage "260" @default.
- W3133490592 startingPage "260" @default.
- W3133490592 abstract "Oxygen availability varies throughout the human body in health and disease. Under physiological conditions, oxygen availability drops from the lungs over the blood stream towards the different tissues into the cells and the mitochondrial cavities leading to physiological low oxygen conditions or physiological hypoxia in all organs including primary lymphoid organs. Moreover, immune cells travel throughout the body searching for damaged cells and foreign antigens facing a variety of oxygen levels. Consequently, physiological hypoxia impacts immune cell function finally controlling innate and adaptive immune response mainly by transcriptional regulation via hypoxia-inducible factors (HIFs). Under pathophysiological conditions such as found in inflammation, injury, infection, ischemia and cancer, severe hypoxia can alter immune cells leading to dysfunctional immune response finally leading to tissue damage, cancer progression and autoimmunity. Here we summarize the effects of physiological and pathophysiological hypoxia on innate and adaptive immune activity, we provide an overview on the control of immune response by cellular hypoxia-induced pathways with focus on the role of HIFs and discuss the opportunity to target hypoxia-sensitive pathways for the treatment of cancer and autoimmunity." @default.
- W3133490592 created "2021-03-15" @default.
- W3133490592 creator A5060426175 @default.
- W3133490592 creator A5074304085 @default.
- W3133490592 date "2021-03-05" @default.
- W3133490592 modified "2023-10-06" @default.
- W3133490592 title "Hypoxia/HIF Modulates Immune Responses" @default.
- W3133490592 cites W1028634185 @default.
- W3133490592 cites W1484043356 @default.
- W3133490592 cites W1506816544 @default.
- W3133490592 cites W1507326555 @default.
- W3133490592 cites W1522165031 @default.
- W3133490592 cites W1534385480 @default.
- W3133490592 cites W1544249031 @default.
- W3133490592 cites W1547863599 @default.
- W3133490592 cites W1548584275 @default.
- W3133490592 cites W1559974225 @default.
- W3133490592 cites W1587828199 @default.
- W3133490592 cites W1595843974 @default.
- W3133490592 cites W1625769635 @default.
- W3133490592 cites W1626917344 @default.
- W3133490592 cites W1663833839 @default.
- W3133490592 cites W1775761483 @default.
- W3133490592 cites W1778788621 @default.
- W3133490592 cites W1797422316 @default.
- W3133490592 cites W1798331267 @default.
- W3133490592 cites W1833218545 @default.
- W3133490592 cites W1842875237 @default.
- W3133490592 cites W1906027219 @default.
- W3133490592 cites W1917241220 @default.
- W3133490592 cites W1917494022 @default.
- W3133490592 cites W1926727282 @default.
- W3133490592 cites W1936396560 @default.
- W3133490592 cites W1937401270 @default.
- W3133490592 cites W1965946201 @default.
- W3133490592 cites W1967727543 @default.
- W3133490592 cites W1968276167 @default.
- W3133490592 cites W1969463979 @default.
- W3133490592 cites W1969734439 @default.
- W3133490592 cites W1970437369 @default.
- W3133490592 cites W1970793031 @default.
- W3133490592 cites W1972558089 @default.
- W3133490592 cites W1973092951 @default.
- W3133490592 cites W1974070070 @default.
- W3133490592 cites W1976302032 @default.
- W3133490592 cites W1978063913 @default.
- W3133490592 cites W1979446481 @default.
- W3133490592 cites W1980690619 @default.
- W3133490592 cites W1981253971 @default.
- W3133490592 cites W1984060145 @default.
- W3133490592 cites W1984752955 @default.
- W3133490592 cites W1986925527 @default.
- W3133490592 cites W1988377666 @default.
- W3133490592 cites W1990423632 @default.
- W3133490592 cites W1991459080 @default.
- W3133490592 cites W1993324234 @default.
- W3133490592 cites W1996168249 @default.
- W3133490592 cites W1997142974 @default.
- W3133490592 cites W1997418415 @default.
- W3133490592 cites W2000178052 @default.
- W3133490592 cites W2000272522 @default.
- W3133490592 cites W2001712545 @default.
- W3133490592 cites W2003670869 @default.
- W3133490592 cites W2005168380 @default.
- W3133490592 cites W2005539293 @default.
- W3133490592 cites W2006236831 @default.
- W3133490592 cites W2008410413 @default.
- W3133490592 cites W2009501393 @default.
- W3133490592 cites W2009547397 @default.
- W3133490592 cites W2010356452 @default.
- W3133490592 cites W2011562442 @default.
- W3133490592 cites W2011846070 @default.
- W3133490592 cites W2013932632 @default.
- W3133490592 cites W2017965105 @default.
- W3133490592 cites W2018504915 @default.
- W3133490592 cites W2020608785 @default.
- W3133490592 cites W2020823643 @default.
- W3133490592 cites W2021947467 @default.
- W3133490592 cites W2022471909 @default.
- W3133490592 cites W2022720370 @default.
- W3133490592 cites W2023259982 @default.
- W3133490592 cites W2024654129 @default.
- W3133490592 cites W2027705428 @default.
- W3133490592 cites W2027904894 @default.
- W3133490592 cites W2027920581 @default.
- W3133490592 cites W2031778182 @default.
- W3133490592 cites W2033289727 @default.
- W3133490592 cites W2033958147 @default.
- W3133490592 cites W2034243112 @default.
- W3133490592 cites W2038689279 @default.
- W3133490592 cites W2039584947 @default.
- W3133490592 cites W2040031153 @default.
- W3133490592 cites W2041418689 @default.
- W3133490592 cites W2043931994 @default.
- W3133490592 cites W2045773985 @default.
- W3133490592 cites W2046037981 @default.
- W3133490592 cites W2046990824 @default.
- W3133490592 cites W2050714142 @default.