FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133514288> ?p ?o ?g. }

• W3133514288 endingPage "109975" @default.
• W3133514288 startingPage "109975" @default.
• W3133514288 abstract "The thirteen-lined ground squirrel is a model fat-storing hibernator that nearly doubles its weight in the fall to fuel metabolism with triglycerides throughout the winter months. Hibernator brown and white adipose tissue (BAT, WAT) are important to study in terms of their inflammatory profile and tissue remodeling mechanisms since controlled and natural regulation of these processes could inform new pharmacological interventions that limit oxidative stress and inflammation in the adipose tissues of humans suffering from obesity, promote non-shivering thermogenesis-mediated weight loss, or prevent tissue damage in transplantable organs emerging from cold-storage. Thus, markers of inflammation like cytokines and soluble receptors and tissue remodeling proteins such as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were investigated in normothermic, torpid, and arousing ground squirrels. Multiplex protein assays and western blotting revealed fewer changes in WAT compared to BAT. Pro-inflammatory IL-1α levels increased during torpor and soluble epidermal growth factor receptor protein levels increased during arousal in BAT. Given their known roles in other model systems, these proteins could regulate processes like adipogenesis, lipid catabolism, or cell motility. Decreased TIMP2 levels combined with maintained MMP2 or MMP3 protein levels suggested that BAT may avoid tissue remodeling until arousal. No changes in WAT inflammatory cytokines or soluble receptors as well as decreased MMP2 levels during torpor and arousal suggested inflammation and modification to the extracellular matrix is likely suppressed in WAT. This study emphasizes the fat-but-fit nature of the hibernating ground squirrel and the ability of its fat stores to suppress inflammation." @default.
• W3133514288 created "2021-03-15" @default.
• W3133514288 creator A5063137585 @default.
• W3133514288 creator A5074785536 @default.
• W3133514288 date "2021-06-01" @default.
• W3133514288 modified "2023-10-18" @default.
• W3133514288 title "Markers of tissue remodeling and inflammation in the white and brown adipose tissues of a model hibernator" @default.
• W3133514288 cites W1870982485 @default.
• W3133514288 cites W1974500456 @default.
• W3133514288 cites W1976418244 @default.
• W3133514288 cites W1985255642 @default.
• W3133514288 cites W2002060477 @default.
• W3133514288 cites W2006099221 @default.
• W3133514288 cites W2006491336 @default.
• W3133514288 cites W2017856783 @default.
• W3133514288 cites W2019434041 @default.
• W3133514288 cites W2021765303 @default.
• W3133514288 cites W2022608749 @default.
• W3133514288 cites W2036518640 @default.
• W3133514288 cites W2038063798 @default.
• W3133514288 cites W2038508652 @default.
• W3133514288 cites W2056046349 @default.
• W3133514288 cites W2061739229 @default.
• W3133514288 cites W2063298867 @default.
• W3133514288 cites W2072013523 @default.
• W3133514288 cites W2090194147 @default.
• W3133514288 cites W2093585592 @default.
• W3133514288 cites W2106038133 @default.
• W3133514288 cites W2108456034 @default.
• W3133514288 cites W2119152901 @default.
• W3133514288 cites W2132290892 @default.
• W3133514288 cites W2145757122 @default.
• W3133514288 cites W2164209362 @default.
• W3133514288 cites W2167617896 @default.
• W3133514288 cites W2253663870 @default.
• W3133514288 cites W2262352837 @default.
• W3133514288 cites W2277094856 @default.
• W3133514288 cites W2323487000 @default.
• W3133514288 cites W2336833178 @default.
• W3133514288 cites W2339913955 @default.
• W3133514288 cites W2341822740 @default.
• W3133514288 cites W2342855211 @default.
• W3133514288 cites W2524376527 @default.
• W3133514288 cites W2538921929 @default.
• W3133514288 cites W2561039222 @default.
• W3133514288 cites W2736346397 @default.
• W3133514288 cites W2760995288 @default.
• W3133514288 cites W2805865421 @default.
• W3133514288 cites W2896582829 @default.
• W3133514288 cites W2896750847 @default.
• W3133514288 cites W3047826055 @default.
• W3133514288 cites W863609049 @default.
• W3133514288 doi "https://doi.org/10.1016/j.cellsig.2021.109975" @default.
• W3133514288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33711429" @default.
• W3133514288 hasPublicationYear "2021" @default.
• W3133514288 type Work @default.
• W3133514288 sameAs 3133514288 @default.
• W3133514288 citedByCount "3" @default.
• W3133514288 countsByYear W31335142882023 @default.
• W3133514288 crossrefType "journal-article" @default.
• W3133514288 hasAuthorship W3133514288A5063137585 @default.
• W3133514288 hasAuthorship W3133514288A5074785536 @default.
• W3133514288 hasConcept C100564792 @default.
• W3133514288 hasConcept C104317684 @default.
• W3133514288 hasConcept C126322002 @default.
• W3133514288 hasConcept C134018914 @default.
• W3133514288 hasConcept C150194340 @default.
• W3133514288 hasConcept C151955695 @default.
• W3133514288 hasConcept C164027704 @default.
• W3133514288 hasConcept C171089720 @default.
• W3133514288 hasConcept C203014093 @default.
• W3133514288 hasConcept C2776914184 @default.
• W3133514288 hasConcept C2779295440 @default.
• W3133514288 hasConcept C2780642333 @default.
• W3133514288 hasConcept C55493867 @default.
• W3133514288 hasConcept C66538056 @default.
• W3133514288 hasConcept C71924100 @default.
• W3133514288 hasConcept C86803240 @default.
• W3133514288 hasConcept C95444343 @default.
• W3133514288 hasConceptScore W3133514288C100564792 @default.
• W3133514288 hasConceptScore W3133514288C104317684 @default.
• W3133514288 hasConceptScore W3133514288C126322002 @default.
• W3133514288 hasConceptScore W3133514288C134018914 @default.
• W3133514288 hasConceptScore W3133514288C150194340 @default.
• W3133514288 hasConceptScore W3133514288C151955695 @default.
• W3133514288 hasConceptScore W3133514288C164027704 @default.
• W3133514288 hasConceptScore W3133514288C171089720 @default.
• W3133514288 hasConceptScore W3133514288C203014093 @default.
• W3133514288 hasConceptScore W3133514288C2776914184 @default.
• W3133514288 hasConceptScore W3133514288C2779295440 @default.
• W3133514288 hasConceptScore W3133514288C2780642333 @default.
• W3133514288 hasConceptScore W3133514288C55493867 @default.
• W3133514288 hasConceptScore W3133514288C66538056 @default.
• W3133514288 hasConceptScore W3133514288C71924100 @default.
• W3133514288 hasConceptScore W3133514288C86803240 @default.
• W3133514288 hasConceptScore W3133514288C95444343 @default.
• W3133514288 hasFunder F4320334593 @default.
• W3133514288 hasLocation W31335142881 @default.

• next