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- W3133518259 endingPage "102284" @default.
- W3133518259 startingPage "102284" @default.
- W3133518259 abstract "We show that C. elegans nematodes learn to associate food with a combination of proprioceptive cues and information on the structure of their surroundings (maze), perceived through mechanosensation. By using the custom-made Worm-Maze platform, we demonstrate that C. elegans young adults can locate food in T-shaped mazes and, following that experience, learn to reach a specific maze arm. C. elegans learning inside the maze is possible after a single training session, it resembles working memory, and it prevails over conflicting environmental cues. We provide evidence that the observed learning is a food-triggered multisensory behavior, which requires mechanosensory and proprioceptive input, and utilizes cues about the structural features of nematodes' environment and their body actions. The CREB-like transcription factor and dopamine signaling are also involved in maze performance. Lastly, we show that the observed aging-driven decline of C. elegans learning ability in the maze can be reversed by starvation." @default.
- W3133518259 created "2021-03-15" @default.
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- W3133518259 date "2021-04-01" @default.
- W3133518259 modified "2023-10-14" @default.
- W3133518259 title "Caenorhabditis elegans learning in a structured maze is a multisensory behavior" @default.
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- W3133518259 doi "https://doi.org/10.1016/j.isci.2021.102284" @default.
- W3133518259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8050377" @default.
- W3133518259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33889812" @default.