Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133555790> ?p ?o ?g. }
- W3133555790 abstract "Abstract mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowledge that mRNA is one of nature’s core building blocks carrying important information and can be considered as a powerful vector for delivery of therapeutic proteins to the patient. For a long time, the major focus in the use of in vitro transcribed mRNA was on development of cancer vaccines, using mRNA encoding tumor antigens to modify dendritic cells ex vivo. However, the versatility of mRNA and its many advantages have paved the path beyond this application. In addition, due to smart design of both the structural properties of the mRNA molecule as well as pharmaceutical formulations that improve its in vivo stability and selective targeting, the therapeutic potential of mRNA can be considered as endless. As a consequence, many novel immunotherapeutic strategies focus on the use of mRNA beyond its use as the source of tumor antigens. This review aims to summarize the state-of-the-art on these applications and to provide a rationale for their clinical application." @default.
- W3133555790 created "2021-03-15" @default.
- W3133555790 creator A5002857731 @default.
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- W3133555790 creator A5048780479 @default.
- W3133555790 date "2021-03-03" @default.
- W3133555790 modified "2023-10-17" @default.
- W3133555790 title "mRNA in cancer immunotherapy: beyond a source of antigen" @default.
- W3133555790 cites W1215958058 @default.
- W3133555790 cites W1523365630 @default.
- W3133555790 cites W1529085705 @default.
- W3133555790 cites W1538766821 @default.
- W3133555790 cites W1577952101 @default.
- W3133555790 cites W1912794777 @default.
- W3133555790 cites W1967369695 @default.
- W3133555790 cites W1969072247 @default.
- W3133555790 cites W1971746066 @default.
- W3133555790 cites W1986178107 @default.
- W3133555790 cites W1990602451 @default.
- W3133555790 cites W2003128034 @default.
- W3133555790 cites W2006862970 @default.
- W3133555790 cites W2009219530 @default.
- W3133555790 cites W2024364873 @default.
- W3133555790 cites W2025980739 @default.
- W3133555790 cites W2028289510 @default.
- W3133555790 cites W2033785641 @default.
- W3133555790 cites W2035277855 @default.
- W3133555790 cites W2041663579 @default.
- W3133555790 cites W2048253455 @default.
- W3133555790 cites W2054412308 @default.
- W3133555790 cites W2058647478 @default.
- W3133555790 cites W2059576566 @default.
- W3133555790 cites W2062853648 @default.
- W3133555790 cites W2071136305 @default.
- W3133555790 cites W2076359982 @default.
- W3133555790 cites W2078572664 @default.
- W3133555790 cites W2089150369 @default.
- W3133555790 cites W2094945699 @default.
- W3133555790 cites W2104597364 @default.
- W3133555790 cites W2106481926 @default.
- W3133555790 cites W2106885643 @default.
- W3133555790 cites W2109280271 @default.
- W3133555790 cites W2110852884 @default.
- W3133555790 cites W2122126544 @default.
- W3133555790 cites W2133105825 @default.
- W3133555790 cites W2135087025 @default.
- W3133555790 cites W2139325323 @default.
- W3133555790 cites W2139399500 @default.
- W3133555790 cites W2139511604 @default.
- W3133555790 cites W2141137217 @default.
- W3133555790 cites W2141208964 @default.
- W3133555790 cites W2142082096 @default.
- W3133555790 cites W2142530756 @default.
- W3133555790 cites W2143015936 @default.
- W3133555790 cites W2143743183 @default.
- W3133555790 cites W2151554822 @default.
- W3133555790 cites W2156382442 @default.
- W3133555790 cites W2156788486 @default.
- W3133555790 cites W2162970812 @default.
- W3133555790 cites W2172537925 @default.
- W3133555790 cites W2194336158 @default.
- W3133555790 cites W2209812019 @default.
- W3133555790 cites W2249755146 @default.
- W3133555790 cites W2290145688 @default.
- W3133555790 cites W2316578928 @default.
- W3133555790 cites W2322553446 @default.
- W3133555790 cites W2327804995 @default.
- W3133555790 cites W2335754269 @default.
- W3133555790 cites W2412158473 @default.
- W3133555790 cites W2417431203 @default.
- W3133555790 cites W2466602492 @default.
- W3133555790 cites W2549131319 @default.
- W3133555790 cites W2555883270 @default.
- W3133555790 cites W2560967803 @default.
- W3133555790 cites W2589417329 @default.
- W3133555790 cites W2589945527 @default.
- W3133555790 cites W2595498373 @default.
- W3133555790 cites W2607356458 @default.
- W3133555790 cites W2617871758 @default.
- W3133555790 cites W2626337750 @default.
- W3133555790 cites W2724264513 @default.
- W3133555790 cites W2731581213 @default.
- W3133555790 cites W2742522266 @default.
- W3133555790 cites W2746455523 @default.
- W3133555790 cites W2748749383 @default.
- W3133555790 cites W2752201538 @default.
- W3133555790 cites W2774533844 @default.
- W3133555790 cites W2782708334 @default.
- W3133555790 cites W2791483720 @default.
- W3133555790 cites W2791782653 @default.
- W3133555790 cites W2791854174 @default.
- W3133555790 cites W2808372952 @default.
- W3133555790 cites W2883190832 @default.
- W3133555790 cites W2884096061 @default.
- W3133555790 cites W2885809926 @default.
- W3133555790 cites W2888196187 @default.