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- W3133557554 abstract "Genetic analyses of patients with amyotrophic lateral sclerosis (ALS) have identified disease-causing mutations and accelerated the unveiling of complex molecular pathogenic mechanisms, which may be important for understanding the disease and developing therapeutic strategies. Many disease-related genes encode RNA-binding proteins, and most of the disease-causing RNA or proteins encoded by these genes form aggregates and disrupt cellular function related to RNA metabolism. Disease-related RNA or proteins interact or sequester other RNA-binding proteins. Eventually, many disease-causing mutations lead to the dysregulation of nucleocytoplasmic shuttling, the dysfunction of stress granules, and the altered dynamic function of the nucleolus as well as other membrane-less organelles. As RNA-binding proteins are usually components of several RNA-binding protein complexes that have other roles, the dysregulation of RNA-binding proteins tends to cause diverse forms of cellular dysfunction. Therefore, understanding the role of RNA-binding proteins will help elucidate the complex pathophysiology of ALS. Here, we summarize the current knowledge regarding the function of disease-associated RNA-binding proteins and their role in the dysfunction of membrane-less organelles." @default.
- W3133557554 created "2021-03-15" @default.
- W3133557554 creator A5024349708 @default.
- W3133557554 creator A5072563772 @default.
- W3133557554 creator A5083198712 @default.
- W3133557554 date "2021-03-05" @default.
- W3133557554 modified "2023-10-17" @default.
- W3133557554 title "RNA-Binding Proteins and the Complex Pathophysiology of ALS" @default.
- W3133557554 cites W1619082318 @default.
- W3133557554 cites W1796096082 @default.
- W3133557554 cites W1797572428 @default.
- W3133557554 cites W1904847174 @default.
- W3133557554 cites W1916595758 @default.
- W3133557554 cites W1941480039 @default.
- W3133557554 cites W1963792170 @default.
- W3133557554 cites W1965286266 @default.
- W3133557554 cites W1974448552 @default.
- W3133557554 cites W1979537665 @default.
- W3133557554 cites W1983466098 @default.
- W3133557554 cites W1984538960 @default.
- W3133557554 cites W1988399759 @default.
- W3133557554 cites W1995222212 @default.
- W3133557554 cites W1995963457 @default.
- W3133557554 cites W1998338379 @default.
- W3133557554 cites W2003618511 @default.
- W3133557554 cites W2004850573 @default.
- W3133557554 cites W2007664874 @default.
- W3133557554 cites W2013488820 @default.
- W3133557554 cites W2015227787 @default.
- W3133557554 cites W2016332933 @default.
- W3133557554 cites W2024351685 @default.
- W3133557554 cites W2024715297 @default.
- W3133557554 cites W2027183714 @default.
- W3133557554 cites W2030906562 @default.
- W3133557554 cites W2032162800 @default.
- W3133557554 cites W2040147159 @default.
- W3133557554 cites W2050234043 @default.
- W3133557554 cites W2054016352 @default.
- W3133557554 cites W2054068057 @default.
- W3133557554 cites W2054542675 @default.
- W3133557554 cites W2060354467 @default.
- W3133557554 cites W2063996210 @default.
- W3133557554 cites W2065219073 @default.
- W3133557554 cites W2065894198 @default.
- W3133557554 cites W2066828509 @default.
- W3133557554 cites W2073073462 @default.
- W3133557554 cites W2075186362 @default.
- W3133557554 cites W2076410921 @default.
- W3133557554 cites W2086896046 @default.
- W3133557554 cites W2087312363 @default.
- W3133557554 cites W2088483634 @default.
- W3133557554 cites W2092751120 @default.
- W3133557554 cites W2096386031 @default.
- W3133557554 cites W2101042581 @default.
- W3133557554 cites W2102813617 @default.
- W3133557554 cites W2112710669 @default.
- W3133557554 cites W2124219443 @default.
- W3133557554 cites W2124834682 @default.
- W3133557554 cites W2127282494 @default.
- W3133557554 cites W2135607950 @default.
- W3133557554 cites W2139871895 @default.
- W3133557554 cites W2143035838 @default.
- W3133557554 cites W2149541702 @default.
- W3133557554 cites W2150443013 @default.
- W3133557554 cites W2150523249 @default.
- W3133557554 cites W2150860983 @default.
- W3133557554 cites W2154945114 @default.
- W3133557554 cites W2156646921 @default.
- W3133557554 cites W2157580663 @default.
- W3133557554 cites W2159354359 @default.
- W3133557554 cites W2163126975 @default.
- W3133557554 cites W2163731275 @default.
- W3133557554 cites W2169158245 @default.
- W3133557554 cites W2169685494 @default.
- W3133557554 cites W2187620259 @default.
- W3133557554 cites W222561556 @default.
- W3133557554 cites W2236156346 @default.
- W3133557554 cites W2309375248 @default.
- W3133557554 cites W2328157766 @default.
- W3133557554 cites W2338545563 @default.
- W3133557554 cites W2346276182 @default.
- W3133557554 cites W2346821877 @default.
- W3133557554 cites W2411532005 @default.
- W3133557554 cites W2478380847 @default.
- W3133557554 cites W2501852726 @default.
- W3133557554 cites W2513196775 @default.
- W3133557554 cites W2520605819 @default.
- W3133557554 cites W2522621368 @default.
- W3133557554 cites W2523823948 @default.
- W3133557554 cites W2533664860 @default.
- W3133557554 cites W2534922319 @default.
- W3133557554 cites W2556818673 @default.
- W3133557554 cites W2586663476 @default.
- W3133557554 cites W2595869676 @default.
- W3133557554 cites W2599965977 @default.
- W3133557554 cites W2604369979 @default.
- W3133557554 cites W2604947514 @default.
- W3133557554 cites W2606642025 @default.