Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133562023> ?p ?o ?g. }
- W3133562023 endingPage "252" @default.
- W3133562023 startingPage "241" @default.
- W3133562023 abstract "Tumor metastasis is one of the major factors for the high mortality in cholangiocarcinoma (CCA), but its underlying mechanisms are not fully understood. Here, we report that Piezo-type mechanosensitive ion channel component 1 (Piezo 1) is detected to be significantly upregulated in CCA tissues, which is linked to a poor prognosis in patients, suggesting that Piezo 1 may act in a pro-metastatic role in CCA development. Piezo 1 is activated through 20% simulated physiological stretch, and deleting Piezo 1 impedes epithelial-to-mesenchymal transition (EMT) of CCA cells, as well as impairing their metastatic capacity <i>in vitro</i> and <i>in vivo</i>. Mechanistically, the activation of Piezo 1 results in large amounts of Yes-associated protein 1 (YAP) translocated into the nucleus from the cytoplasm, and thus the motility of CCA cells is significantly increased. These findings indicate that mechanical stimulation induces Piezo 1 activation, which might be involved in CCA metastasis via the Hippo/YAP signaling axis. Therefore, Piezo 1 and its downstream effectors may be a novel therapeutic target for CCA treatment." @default.
- W3133562023 created "2021-03-15" @default.
- W3133562023 creator A5023933073 @default.
- W3133562023 creator A5033184102 @default.
- W3133562023 creator A5035153981 @default.
- W3133562023 creator A5038427310 @default.
- W3133562023 creator A5044898446 @default.
- W3133562023 date "2021-06-01" @default.
- W3133562023 modified "2023-10-11" @default.
- W3133562023 title "Piezo 1 activation facilitates cholangiocarcinoma metastasis via Hippo/YAP signaling axis" @default.
- W3133562023 cites W1888543545 @default.
- W3133562023 cites W1996711923 @default.
- W3133562023 cites W2000241906 @default.
- W3133562023 cites W2026506883 @default.
- W3133562023 cites W2047848650 @default.
- W3133562023 cites W2086244192 @default.
- W3133562023 cites W2149079172 @default.
- W3133562023 cites W2171157655 @default.
- W3133562023 cites W2226696232 @default.
- W3133562023 cites W2265398540 @default.
- W3133562023 cites W2507196425 @default.
- W3133562023 cites W2562001879 @default.
- W3133562023 cites W2579719458 @default.
- W3133562023 cites W2588123864 @default.
- W3133562023 cites W2742885310 @default.
- W3133562023 cites W2747643344 @default.
- W3133562023 cites W2763492611 @default.
- W3133562023 cites W2785150634 @default.
- W3133562023 cites W2791031844 @default.
- W3133562023 cites W2793363299 @default.
- W3133562023 cites W2794799252 @default.
- W3133562023 cites W2796289568 @default.
- W3133562023 cites W2801055205 @default.
- W3133562023 cites W2801882320 @default.
- W3133562023 cites W2808032803 @default.
- W3133562023 cites W2890627306 @default.
- W3133562023 cites W2891780076 @default.
- W3133562023 cites W2906067435 @default.
- W3133562023 cites W2920622910 @default.
- W3133562023 cites W2922005485 @default.
- W3133562023 cites W2924822859 @default.
- W3133562023 cites W2942454265 @default.
- W3133562023 cites W2946065961 @default.
- W3133562023 cites W2948798639 @default.
- W3133562023 cites W2951672374 @default.
- W3133562023 cites W2953578471 @default.
- W3133562023 cites W2969551943 @default.
- W3133562023 cites W2981769112 @default.
- W3133562023 cites W3003833289 @default.
- W3133562023 cites W4235961884 @default.
- W3133562023 cites W626431186 @default.
- W3133562023 doi "https://doi.org/10.1016/j.omtn.2021.02.026" @default.
- W3133562023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7973248" @default.
- W3133562023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33767919" @default.
- W3133562023 hasPublicationYear "2021" @default.
- W3133562023 type Work @default.
- W3133562023 sameAs 3133562023 @default.
- W3133562023 citedByCount "22" @default.
- W3133562023 countsByYear W31335620232021 @default.
- W3133562023 countsByYear W31335620232022 @default.
- W3133562023 countsByYear W31335620232023 @default.
- W3133562023 crossrefType "journal-article" @default.
- W3133562023 hasAuthorship W3133562023A5023933073 @default.
- W3133562023 hasAuthorship W3133562023A5033184102 @default.
- W3133562023 hasAuthorship W3133562023A5035153981 @default.
- W3133562023 hasAuthorship W3133562023A5038427310 @default.
- W3133562023 hasAuthorship W3133562023A5044898446 @default.
- W3133562023 hasBestOaLocation W31335620232 @default.
- W3133562023 hasConcept C104317684 @default.
- W3133562023 hasConcept C121608353 @default.
- W3133562023 hasConcept C126322002 @default.
- W3133562023 hasConcept C127561419 @default.
- W3133562023 hasConcept C150903083 @default.
- W3133562023 hasConcept C169760540 @default.
- W3133562023 hasConcept C170493617 @default.
- W3133562023 hasConcept C172512520 @default.
- W3133562023 hasConcept C181104049 @default.
- W3133562023 hasConcept C185592680 @default.
- W3133562023 hasConcept C190062978 @default.
- W3133562023 hasConcept C207001950 @default.
- W3133562023 hasConcept C24998067 @default.
- W3133562023 hasConcept C2779013556 @default.
- W3133562023 hasConcept C4001165 @default.
- W3133562023 hasConcept C50254741 @default.
- W3133562023 hasConcept C502942594 @default.
- W3133562023 hasConcept C51785407 @default.
- W3133562023 hasConcept C55493867 @default.
- W3133562023 hasConcept C58207958 @default.
- W3133562023 hasConcept C71924100 @default.
- W3133562023 hasConcept C76419328 @default.
- W3133562023 hasConcept C86803240 @default.
- W3133562023 hasConcept C95444343 @default.
- W3133562023 hasConceptScore W3133562023C104317684 @default.
- W3133562023 hasConceptScore W3133562023C121608353 @default.
- W3133562023 hasConceptScore W3133562023C126322002 @default.
- W3133562023 hasConceptScore W3133562023C127561419 @default.
- W3133562023 hasConceptScore W3133562023C150903083 @default.
- W3133562023 hasConceptScore W3133562023C169760540 @default.