FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133574075> ?p ?o ?g. }

• W3133574075 endingPage "599" @default.
• W3133574075 startingPage "583" @default.
• W3133574075 abstract "Several novel beta-lactams (BLs) and/or beta lactams/beta-lactamase inhibitors (BL/BLIs) have been recently developed for the management of multidrug-resistant bacterial infections. Data concerning dose optimization in critically ill patients with altered renal function are scanty.This article provides a critical reappraisal of pharmacokinetic and clinical issues emerged with novel BLs and/or BL/BLIs in renal critically ill patients. Clinical and pharmacokinetic studies published in English until December 2020 were searched on the PubMed-MEDLINE database.Several issues emerged with the use of novel BLs and/or BL/BLIs in critically ill renal patients. Suboptimal clinical response rate with ceftazidime-avibactam and ceftolozane-tazobactam was reported in phase II-III trials in patients with moderate kidney injury; data on patients undergoing renal replacement therapy are limited to some case reports; dose adjustment in augmented renal clearance is provided only for cefiderocol. Implementation of altered dosing strategies (prolonged infusion and/or higher dosage) coupled with adaptive real-time therapeutic drug monitoring could represent the most effective approach in warranting optimal pharmacokinetic/pharmacodynamic targets with novel BLs and/or BL/BLIs in challenging scenarios, thus minimizing the risk of clinical failure and/or of resistance selection." @default.
• W3133574075 created "2021-03-15" @default.
• W3133574075 creator A5040568455 @default.
• W3133574075 creator A5071687756 @default.
• W3133574075 date "2021-05-01" @default.
• W3133574075 modified "2023-09-26" @default.
• W3133574075 title "Pharmacokinetic/pharmacodynamic target attainment in critically ill renal patients on antimicrobial usage: focus on novel beta-lactams and beta lactams/beta-lactamase inhibitors." @default.
• W3133574075 cites W1531106656 @default.
• W3133574075 cites W1881490801 @default.
• W3133574075 cites W1922399270 @default.
• W3133574075 cites W1969500929 @default.
• W3133574075 cites W1971624521 @default.
• W3133574075 cites W1993397663 @default.
• W3133574075 cites W1994992293 @default.
• W3133574075 cites W2004888852 @default.
• W3133574075 cites W2015329932 @default.
• W3133574075 cites W2016744329 @default.
• W3133574075 cites W2017947220 @default.
• W3133574075 cites W2027548739 @default.
• W3133574075 cites W2045006060 @default.
• W3133574075 cites W2046281708 @default.
• W3133574075 cites W2056612376 @default.
• W3133574075 cites W2066608027 @default.
• W3133574075 cites W2079691262 @default.
• W3133574075 cites W2080374429 @default.
• W3133574075 cites W2082321986 @default.
• W3133574075 cites W2093073135 @default.
• W3133574075 cites W2098013607 @default.
• W3133574075 cites W2099916537 @default.
• W3133574075 cites W2101416655 @default.
• W3133574075 cites W2114807886 @default.
• W3133574075 cites W2121189212 @default.
• W3133574075 cites W2136494304 @default.
• W3133574075 cites W2140063054 @default.
• W3133574075 cites W2145226012 @default.
• W3133574075 cites W2149687213 @default.
• W3133574075 cites W2149974939 @default.
• W3133574075 cites W2150729119 @default.
• W3133574075 cites W2153641174 @default.
• W3133574075 cites W2159478871 @default.
• W3133574075 cites W2164990391 @default.
• W3133574075 cites W2171879266 @default.
• W3133574075 cites W2172887702 @default.
• W3133574075 cites W2179850291 @default.
• W3133574075 cites W2199091941 @default.
• W3133574075 cites W2239960209 @default.
• W3133574075 cites W2294833633 @default.
• W3133574075 cites W2298261704 @default.
• W3133574075 cites W2307357170 @default.
• W3133574075 cites W2316297039 @default.
• W3133574075 cites W2462059638 @default.
• W3133574075 cites W2466717036 @default.
• W3133574075 cites W2566236568 @default.
• W3133574075 cites W2592564124 @default.
• W3133574075 cites W2602249829 @default.
• W3133574075 cites W2606693819 @default.
• W3133574075 cites W2736611040 @default.
• W3133574075 cites W2766636752 @default.
• W3133574075 cites W2767038067 @default.
• W3133574075 cites W2767258537 @default.
• W3133574075 cites W2768193816 @default.
• W3133574075 cites W2771362836 @default.
• W3133574075 cites W2775239537 @default.
• W3133574075 cites W2792380978 @default.
• W3133574075 cites W2792731513 @default.
• W3133574075 cites W2796052358 @default.
• W3133574075 cites W2886914797 @default.
• W3133574075 cites W2892028816 @default.
• W3133574075 cites W2894551919 @default.
• W3133574075 cites W2895593384 @default.
• W3133574075 cites W2896718967 @default.
• W3133574075 cites W2897055654 @default.
• W3133574075 cites W2899536177 @default.
• W3133574075 cites W2899682145 @default.
• W3133574075 cites W2904454862 @default.
• W3133574075 cites W2910433587 @default.
• W3133574075 cites W2913385089 @default.
• W3133574075 cites W2913445675 @default.
• W3133574075 cites W2916181671 @default.
• W3133574075 cites W2922087021 @default.
• W3133574075 cites W2929478224 @default.
• W3133574075 cites W2946775228 @default.
• W3133574075 cites W2946933455 @default.
• W3133574075 cites W2962033621 @default.
• W3133574075 cites W2963222371 @default.
• W3133574075 cites W2964349392 @default.
• W3133574075 cites W2965452221 @default.
• W3133574075 cites W2967198136 @default.
• W3133574075 cites W2970215031 @default.
• W3133574075 cites W2972833876 @default.
• W3133574075 cites W2975920332 @default.
• W3133574075 cites W2977924451 @default.
• W3133574075 cites W2980288499 @default.
• W3133574075 cites W2982057538 @default.
• W3133574075 cites W2982369828 @default.
• W3133574075 cites W2983446329 @default.
• W3133574075 cites W2986443682 @default.
• W3133574075 cites W2989089762 @default.

• next