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• W3133587783 abstract "Abstract Protein–protein interactions (PPIs) between modular binding domains and their target peptide motifs are thought to largely depend on the intrinsic binding specificities of the domains. The large family of SRC Homology 3 (SH3) domains contribute to cellular processes via their ability to support such PPIs. While the intrinsic binding specificities of SH3 domains have been studied in vitro, whether each domain is necessary and sufficient to define PPI specificity in vivo is largely unknown. Here, by combining deletion, mutation, swapping and shuffling of SH3 domains and measurements of their impact on protein interactions in yeast, we find that most SH3s do not dictate PPI specificity independently from their host protein in vivo. We show that the identity of the host protein and the position of the SH3 domains within their host are critical for PPI specificity, for cellular functions and for key biophysical processes such as phase separation. Our work demonstrates the importance of the interplay between a modular PPI domain such as SH3 and its host protein in establishing specificity to wire PPI networks. These findings will aid understanding how protein networks are rewired during evolution and in the context of mutation-driven diseases such as cancer." @default.
• W3133587783 created "2021-03-15" @default.
• W3133587783 creator A5001460168 @default.
• W3133587783 creator A5017046589 @default.
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• W3133587783 creator A5089044952 @default.
• W3133587783 date "2021-03-12" @default.
• W3133587783 modified "2023-10-17" @default.
• W3133587783 title "Protein context shapes the specificity of SH3 domain-mediated interactions in vivo" @default.
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• W3133587783 cites W1894813487 @default.
• W3133587783 cites W1964328150 @default.
• W3133587783 cites W1986656413 @default.
• W3133587783 cites W1989873812 @default.
• W3133587783 cites W1993591356 @default.
• W3133587783 cites W1995404781 @default.
• W3133587783 cites W2006054867 @default.
• W3133587783 cites W2006124679 @default.
• W3133587783 cites W2008708467 @default.
• W3133587783 cites W2013947447 @default.
• W3133587783 cites W2015159529 @default.
• W3133587783 cites W2018407607 @default.
• W3133587783 cites W2019453493 @default.
• W3133587783 cites W2022204362 @default.
• W3133587783 cites W2023124677 @default.
• W3133587783 cites W2024962796 @default.
• W3133587783 cites W2027974246 @default.
• W3133587783 cites W2044084413 @default.
• W3133587783 cites W2045472566 @default.
• W3133587783 cites W2047995544 @default.
• W3133587783 cites W2055115999 @default.
• W3133587783 cites W2058922567 @default.
• W3133587783 cites W2059477980 @default.
• W3133587783 cites W2071920845 @default.
• W3133587783 cites W2086900521 @default.
• W3133587783 cites W2089273345 @default.
• W3133587783 cites W2091377998 @default.
• W3133587783 cites W2094036688 @default.
• W3133587783 cites W2096057003 @default.
• W3133587783 cites W2097356092 @default.
• W3133587783 cites W2100203037 @default.
• W3133587783 cites W2101231992 @default.
• W3133587783 cites W2101370506 @default.
• W3133587783 cites W2102502076 @default.
• W3133587783 cites W2102572519 @default.
• W3133587783 cites W2104488053 @default.
• W3133587783 cites W2105689851 @default.
• W3133587783 cites W2108234281 @default.
• W3133587783 cites W2110311701 @default.
• W3133587783 cites W2116045343 @default.
• W3133587783 cites W2119411909 @default.
• W3133587783 cites W2125272201 @default.
• W3133587783 cites W2128711701 @default.
• W3133587783 cites W2133172947 @default.
• W3133587783 cites W2137104501 @default.
• W3133587783 cites W2137111266 @default.
• W3133587783 cites W2140996283 @default.
• W3133587783 cites W2141834983 @default.
• W3133587783 cites W2142437744 @default.
• W3133587783 cites W2144939475 @default.
• W3133587783 cites W2148315081 @default.
• W3133587783 cites W2154319440 @default.
• W3133587783 cites W2163485494 @default.
• W3133587783 cites W2169805130 @default.
• W3133587783 cites W2170551349 @default.
• W3133587783 cites W2189707966 @default.
• W3133587783 cites W2194477621 @default.
• W3133587783 cites W2281531600 @default.
• W3133587783 cites W2339738230 @default.
• W3133587783 cites W2342644652 @default.
• W3133587783 cites W2344328354 @default.
• W3133587783 cites W2411304212 @default.
• W3133587783 cites W2434255706 @default.
• W3133587783 cites W2511139994 @default.
• W3133587783 cites W2606956542 @default.
• W3133587783 cites W2606957126 @default.
• W3133587783 cites W2750589052 @default.
• W3133587783 cites W2786505886 @default.
• W3133587783 cites W2790971222 @default.
• W3133587783 cites W2792119560 @default.
• W3133587783 cites W2804379803 @default.
• W3133587783 cites W2809080492 @default.
• W3133587783 cites W2898221567 @default.
• W3133587783 cites W2898402099 @default.
• W3133587783 cites W2946813309 @default.
• W3133587783 cites W2951912016 @default.
• W3133587783 cites W2997482957 @default.
• W3133587783 cites W3136918052 @default.
• W3133587783 cites W3212388528 @default.

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