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- W3133603350 endingPage "389" @default.
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- W3133603350 abstract "The development of cancer stems from genetic instability and changes in genomic sequences, and hence, the heterogeneity exhibited by tumors is integral to the nature of cancer itself. Tumor heterogeneity can be further altered by factors that are not cancer cell intrinsic, i.e., by the microenvironment, including the patient’s immune responses to tumors and administered therapies (immunotherapies, chemotherapies, and/or radiation therapies). The focus of this review is the impact of tumor heterogeneity on the interactions between immune cells and the tumor, taking into account that heterogeneity can exist at several levels. These levels include heterogeneity within an individual tumor, within an individual patient (particularly between the primary tumor and metastatic lesions), among the subtypes of a specific type of cancer, or within cancers that originate from different tissues. Because of the potential for immunity (either the natural immune system or via immunotherapeutics) to halt the progression of cancer, major clinical significance exists in understanding the impact of tumor heterogeneity on the associations between immune cells and tumor cells. Increased knowledge of why, whether, and how immune-tumor interactions occur provides the means to guide these interactions and improve outcomes for patients." @default.
- W3133603350 created "2021-03-15" @default.
- W3133603350 creator A5011452994 @default.
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- W3133603350 creator A5047278765 @default.
- W3133603350 creator A5065758067 @default.
- W3133603350 creator A5086505077 @default.
- W3133603350 date "2021-03-08" @default.
- W3133603350 modified "2023-10-14" @default.
- W3133603350 title "The role of tumor heterogeneity in immune-tumor interactions" @default.
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- W3133603350 doi "https://doi.org/10.1007/s10555-021-09957-3" @default.
- W3133603350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8220647" @default.
- W3133603350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33682030" @default.
- W3133603350 hasPublicationYear "2021" @default.