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- W3133604444 abstract "Aberrant regulation of angiogenesis involves in the growth and metastasis of tumors, but angiogenesis inhibitors fail to improve overall survival of pancreatic cancer patients in previous phase III clinical trials. A comprehensive knowledge of the mechanism of angiogenesis inhibitors against pancreatic cancer is helpful for clinical purpose and for the selection of patients who might benefit from the inhibitors. In this work, multi-omics analyses (transcriptomics, proteomics, and phosphoproteomics profiling) were carried out to delineate the mechanism of anlotinib, a novel angiogenesis inhibitor, against pancreatic cancer cells. The results showed that anlotinib exerted noteworthy cytotoxicity on pancreatic cancer cells. Multi-omics analyses revealed that anlotinib had a profound inhibitory effect on ribosome, and regulated cell cycle, RNA metabolism and lysosome. Based on the multi-omics results and available data deposited in public databases, an anlotinib-related gene signature was further constructed to identify a subgroup of pancreatic cancer patients who had a dismal prognosis and might be responsive to anlotinib." @default.
- W3133604444 created "2021-03-15" @default.
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- W3133604444 date "2021-03-04" @default.
- W3133604444 modified "2023-10-12" @default.
- W3133604444 title "Multi-Omics Analysis of Anlotinib in Pancreatic Cancer and Development of an Anlotinib-Related Prognostic Signature" @default.
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- W3133604444 cites W1950538286 @default.
- W3133604444 cites W1976156924 @default.
- W3133604444 cites W2034669380 @default.
- W3133604444 cites W2035618305 @default.
- W3133604444 cites W2037199116 @default.
- W3133604444 cites W2049533157 @default.
- W3133604444 cites W2060187655 @default.
- W3133604444 cites W2071058912 @default.
- W3133604444 cites W2082502572 @default.
- W3133604444 cites W2096057003 @default.
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- W3133604444 cites W2102752109 @default.
- W3133604444 cites W2119242310 @default.
- W3133604444 cites W2128095147 @default.
- W3133604444 cites W2137508065 @default.
- W3133604444 cites W2151252396 @default.
- W3133604444 cites W2155167083 @default.
- W3133604444 cites W2155363874 @default.
- W3133604444 cites W2156663446 @default.
- W3133604444 cites W2161579181 @default.
- W3133604444 cites W2162778008 @default.
- W3133604444 cites W2169322031 @default.
- W3133604444 cites W2224400747 @default.
- W3133604444 cites W2341866865 @default.
- W3133604444 cites W2398276458 @default.
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- W3133604444 cites W2508653883 @default.
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- W3133604444 cites W2590466776 @default.
- W3133604444 cites W2605873159 @default.
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- W3133604444 cites W2763077107 @default.
- W3133604444 cites W2766212588 @default.
- W3133604444 cites W2766715686 @default.
- W3133604444 cites W2773619385 @default.
- W3133604444 cites W2787358630 @default.
- W3133604444 cites W2791667474 @default.
- W3133604444 cites W2793323124 @default.
- W3133604444 cites W2793605704 @default.
- W3133604444 cites W2794857100 @default.
- W3133604444 cites W2808043936 @default.
- W3133604444 cites W2834127074 @default.
- W3133604444 cites W2885503610 @default.
- W3133604444 cites W2888158159 @default.
- W3133604444 cites W2888288679 @default.
- W3133604444 cites W2889570909 @default.
- W3133604444 cites W2895684352 @default.
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- W3133604444 cites W2910848742 @default.
- W3133604444 cites W2914703963 @default.
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- W3133604444 cites W2922400209 @default.
- W3133604444 cites W2923519145 @default.
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- W3133604444 cites W2936300667 @default.
- W3133604444 cites W2936906264 @default.
- W3133604444 cites W2937017479 @default.
- W3133604444 cites W2944290286 @default.
- W3133604444 cites W2945629440 @default.
- W3133604444 cites W2969220132 @default.
- W3133604444 cites W2972145333 @default.
- W3133604444 cites W2979651377 @default.
- W3133604444 cites W2982595724 @default.
- W3133604444 cites W2985150468 @default.
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- W3133604444 cites W3044745358 @default.
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- W3133604444 doi "https://doi.org/10.3389/fcell.2021.649265" @default.
- W3133604444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7969999" @default.
- W3133604444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33748143" @default.
- W3133604444 hasPublicationYear "2021" @default.
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