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- W3133609 abstract "Groups of patients with dendritic ulcers, persistent stromal disease, together with a group of controls were investigated for humoral and cell mediated immune responses in order to find whether correlation exists between disease severity and these in vitro tests. Kinetic studies of cell mediated immune responses were also carried out in a small group of patients. Using a whole blood test of lymphocyte transformation to HSV antigen, there was some evidence of a depression of specific response in patients with stromal disease. Primary herpetic keratitis was associated with a considerable positive response in lymphocyte transformation and in the production of macrophage migration inhibition factor. Recurrent disease was associated with elevation of specific lymphocyte transformation during active disease, which fell to a normal resting level during convalescence. Although there was a tendency towards increased frequency in HL-A 1 in patients with dendritic ulcers which was not apparent in stromal disease, this trend did not reach statistical significance. Since lymphocyte transformation using specific virus antigen was the only in vitro correlate of clinical severity, it is concluded that it can be recommended as a useful test to determine patients at risk of developing the more serious forms of keratitis." @default.
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- W3133609 date "1981-01-01" @default.
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- W3133609 title "Factors Influencing the Spread of Herpes Simplex Virus Into the Corneal Stroma" @default.
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- W3133609 doi "https://doi.org/10.1007/978-3-642-80499-1_20" @default.
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