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- W3133611223 abstract "As next-generation artificial enzymes, nanozymes have shown great promise for tumor catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze hydrogen peroxide (H2O2) to produce highly toxic hydroxyl radicals (•OH) to kill tumor cells. However, limited by the low affinity between nanozymes with H2O2 and the low level of H2O2 in the tumor microenvironment, peroxidase nanozymes usually produced insufficient •OH to kill tumor cells for therapeutic purposes. Herein, we present a pyrite peroxidase nanozyme with ultrahigh H2O2 affinity, resulting in a 4144- and 3086-fold increase of catalytic activity compared with that of classical Fe3O4 nanozyme and natural horseradish peroxidase, respectively. We found that the pyrite nanozyme also possesses intrinsic glutathione oxidase-like activity, which catalyzes the oxidation of reduced glutathione accompanied by H2O2 generation. Thus, the dual-activity pyrite nanozyme constitutes a self-cascade platform to generate abundant •OH and deplete reduced glutathione, which induces apoptosis as well as ferroptosis of tumor cells. Consequently, it killed apoptosis-resistant tumor cells harboring KRAS mutation by inducing ferroptosis. The pyrite nanozyme also exhibited favorable tumor-specific cytotoxicity and biodegradability to ensure its biosafety. These results indicate that the high-performance pyrite nanozyme is an effective therapeutic reagent and may aid the development of nanozyme-based tumor catalytic therapy." @default.
- W3133611223 created "2021-03-15" @default.
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- W3133611223 date "2021-03-11" @default.
- W3133611223 modified "2023-10-16" @default.
- W3133611223 title "High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy" @default.
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- W3133611223 cites W1990455420 @default.
- W3133611223 cites W1990796256 @default.
- W3133611223 cites W1991225025 @default.
- W3133611223 cites W1995279009 @default.
- W3133611223 cites W2008878539 @default.
- W3133611223 cites W2042619042 @default.
- W3133611223 cites W2061136308 @default.
- W3133611223 cites W2067938944 @default.
- W3133611223 cites W2087347929 @default.
- W3133611223 cites W2095658597 @default.
- W3133611223 cites W2109818797 @default.
- W3133611223 cites W2110721989 @default.
- W3133611223 cites W2116796524 @default.
- W3133611223 cites W2145010618 @default.
- W3133611223 cites W2163326536 @default.
- W3133611223 cites W2170913114 @default.
- W3133611223 cites W2189205651 @default.
- W3133611223 cites W2189968318 @default.
- W3133611223 cites W2304436920 @default.
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- W3133611223 cites W2312624944 @default.
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- W3133611223 cites W2396166154 @default.
- W3133611223 cites W2478711226 @default.
- W3133611223 cites W2492923874 @default.
- W3133611223 cites W2549697151 @default.
- W3133611223 cites W2558420074 @default.
- W3133611223 cites W2562404168 @default.
- W3133611223 cites W2586240677 @default.
- W3133611223 cites W2737010615 @default.
- W3133611223 cites W2747423355 @default.
- W3133611223 cites W2750778799 @default.
- W3133611223 cites W2762087180 @default.
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- W3133611223 cites W2791613310 @default.
- W3133611223 cites W2795094503 @default.
- W3133611223 cites W2800971234 @default.
- W3133611223 cites W2884787683 @default.
- W3133611223 cites W2898371604 @default.
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- W3133611223 cites W2902416943 @default.
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- W3133611223 cites W2939712722 @default.
- W3133611223 cites W2942526017 @default.
- W3133611223 cites W2945559744 @default.
- W3133611223 cites W2945901473 @default.
- W3133611223 cites W2955231196 @default.
- W3133611223 cites W2969836098 @default.
- W3133611223 cites W2974980488 @default.
- W3133611223 cites W2981090294 @default.
- W3133611223 cites W2981574762 @default.
- W3133611223 cites W2984051992 @default.
- W3133611223 cites W2996592310 @default.
- W3133611223 cites W2998560245 @default.
- W3133611223 cites W3005173588 @default.
- W3133611223 cites W3012907231 @default.
- W3133611223 cites W3014165543 @default.
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- W3133611223 doi "https://doi.org/10.1021/acsnano.1c01248" @default.
- W3133611223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33705663" @default.
- W3133611223 hasPublicationYear "2021" @default.
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