Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133631407> ?p ?o ?g. }
- W3133631407 endingPage "332" @default.
- W3133631407 startingPage "323" @default.
- W3133631407 abstract "Malignant primary and secondary brain tumors pose a major health challenge, and the incidence of these tumors is rising. The brain tumor microenvironment (TME) is highly complex and thought to impact treatment resistance and failure. To enable a greater understanding of the milieu of cells in the brain TME, advances in imaging and sequential profiling of proteins/mRNA have given rise to the field of spatial transcriptomics. These technologies provide a greater depth of understanding of the tissue architecture, cellular and spatial profiles, including cellular activation status, which may provide insights into effective therapies for brain cancers.In this review, we provide an overview of spatial profiling technologies at the forefront in the field and describe the applications for brain cancer.Brain tumors are often resistant to treatment, and display both an immunosuppressive and heterogeneous tumor microenvironment. Next-generation imaging and multi-omics technologies are providing a tool for intricately characterizing their tissue biology. This information will aid in the design of effective therapies and begin to provide an understanding of therapy resistance." @default.
- W3133631407 created "2021-03-15" @default.
- W3133631407 creator A5030525901 @default.
- W3133631407 creator A5033519199 @default.
- W3133631407 creator A5035619061 @default.
- W3133631407 creator A5047329745 @default.
- W3133631407 creator A5081701394 @default.
- W3133631407 creator A5091302244 @default.
- W3133631407 date "2021-03-04" @default.
- W3133631407 modified "2023-09-25" @default.
- W3133631407 title "Spatial profiling technologies and applications for brain cancers" @default.
- W3133631407 cites W1979240391 @default.
- W3133631407 cites W1992015017 @default.
- W3133631407 cites W1996908572 @default.
- W3133631407 cites W1999419270 @default.
- W3133631407 cites W2027267723 @default.
- W3133631407 cites W2030017878 @default.
- W3133631407 cites W2042789810 @default.
- W3133631407 cites W2047930883 @default.
- W3133631407 cites W2058689904 @default.
- W3133631407 cites W2088993386 @default.
- W3133631407 cites W2107731685 @default.
- W3133631407 cites W2108938302 @default.
- W3133631407 cites W2142242761 @default.
- W3133631407 cites W2143078369 @default.
- W3133631407 cites W2161289668 @default.
- W3133631407 cites W2171074831 @default.
- W3133631407 cites W2175940415 @default.
- W3133631407 cites W2269193607 @default.
- W3133631407 cites W2280099094 @default.
- W3133631407 cites W2366536035 @default.
- W3133631407 cites W2395943362 @default.
- W3133631407 cites W2537666096 @default.
- W3133631407 cites W2549204228 @default.
- W3133631407 cites W2550247089 @default.
- W3133631407 cites W2585179645 @default.
- W3133631407 cites W2603523955 @default.
- W3133631407 cites W2620651944 @default.
- W3133631407 cites W2624310346 @default.
- W3133631407 cites W2763776271 @default.
- W3133631407 cites W2794627893 @default.
- W3133631407 cites W2802561340 @default.
- W3133631407 cites W2806597619 @default.
- W3133631407 cites W2884741638 @default.
- W3133631407 cites W2889646458 @default.
- W3133631407 cites W2893457968 @default.
- W3133631407 cites W2894584497 @default.
- W3133631407 cites W2894796660 @default.
- W3133631407 cites W2899224111 @default.
- W3133631407 cites W2902520446 @default.
- W3133631407 cites W2916892496 @default.
- W3133631407 cites W2917392301 @default.
- W3133631407 cites W2945690674 @default.
- W3133631407 cites W2947751399 @default.
- W3133631407 cites W2948321041 @default.
- W3133631407 cites W2949315168 @default.
- W3133631407 cites W2949575059 @default.
- W3133631407 cites W2951880440 @default.
- W3133631407 cites W2952459265 @default.
- W3133631407 cites W2953611213 @default.
- W3133631407 cites W2961217357 @default.
- W3133631407 cites W2972983657 @default.
- W3133631407 cites W2978668158 @default.
- W3133631407 cites W2979984433 @default.
- W3133631407 cites W2980057502 @default.
- W3133631407 cites W2980933209 @default.
- W3133631407 cites W2983984892 @default.
- W3133631407 cites W2995345254 @default.
- W3133631407 cites W2999681746 @default.
- W3133631407 cites W3007876418 @default.
- W3133631407 cites W3008188998 @default.
- W3133631407 cites W3009669074 @default.
- W3133631407 cites W3017039519 @default.
- W3133631407 cites W3021920958 @default.
- W3133631407 cites W3030308289 @default.
- W3133631407 cites W3030339055 @default.
- W3133631407 cites W3032266082 @default.
- W3133631407 cites W3032465961 @default.
- W3133631407 cites W3036882247 @default.
- W3133631407 cites W3046388427 @default.
- W3133631407 cites W3092450854 @default.
- W3133631407 cites W3106675982 @default.
- W3133631407 cites W3107455121 @default.
- W3133631407 cites W3108853735 @default.
- W3133631407 cites W3120342826 @default.
- W3133631407 cites W4211220688 @default.
- W3133631407 cites W4211260961 @default.
- W3133631407 doi "https://doi.org/10.1080/14737159.2021.1900735" @default.
- W3133631407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33685321" @default.
- W3133631407 hasPublicationYear "2021" @default.
- W3133631407 type Work @default.
- W3133631407 sameAs 3133631407 @default.
- W3133631407 citedByCount "11" @default.
- W3133631407 countsByYear W31336314072021 @default.
- W3133631407 countsByYear W31336314072022 @default.
- W3133631407 countsByYear W31336314072023 @default.
- W3133631407 crossrefType "journal-article" @default.
- W3133631407 hasAuthorship W3133631407A5030525901 @default.