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- W3133665030 abstract "ABSTRACT A successful HIV vaccine must overcome the hurdle of being able to activate naïve precursor B cells encoding features within their germline B cell receptors (BCR) that allow recognition of broadly neutralizing epitopes. Knowledge of whether broadly neutralizing antibody (bnAb) precursor B cells are circulating at sufficient frequencies within individuals in communities heavily impacted by HIV may be important. Using a germline-targeting eOD-GT8 immunogen and high-throughput droplet-based single cell BCR sequencing, we demonstrate that large numbers of paired BCR sequences from multiple donors can be efficiently screened to elucidate precursor frequencies of rare, naïve VRC01-class B cells. The results indicate that IGHV1-2 alleles incompatible with VRC01-class responses are relatively common in various human populations, and germline variation within IGHV1-2 associates with gene usage frequencies in the naïve BCR repertoire." @default.
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- W3133665030 date "2021-03-02" @default.
- W3133665030 modified "2023-10-14" @default.
- W3133665030 title "Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells" @default.
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- W3133665030 doi "https://doi.org/10.1101/2021.03.01.433480" @default.
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