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• W3133666077 abstract "Glial cells (astrocytes, oligodendrocytes, and microglia) are emerging as key players in several physiological and pathological processes of the central nervous system (CNS). Astrocytes and oligodendrocytes are not only supportive cells that release trophic factors or regulate energy metabolism, but they also actively modulate critical neuronal processes and functions in the tripartite synapse. Microglia are defined as CNS-resident cells that provide immune surveillance; however, they also actively contribute to shaping the neuronal microenvironment by scavenging cell debris or regulating synaptogenesis and pruning. Given the many interconnected processes coordinated by glial cells, it is not surprising that both acute and chronic CNS insults not only cause neuronal damage but also trigger complex multifaceted responses, including neuroinflammation, which can critically contribute to the disease progression and worsening of symptoms in several neurodegenerative diseases. Overall, this makes glial cells excellent candidates for targeted therapies to treat CNS disorders. In recent years, the application of gene editing technologies has redefined therapeutic strategies to treat genetic and age-related neurological diseases. In this review, we discuss the advantages and limitations of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-based gene editing in the treatment of neurodegenerative disorders, focusing on the development of viral- and nanoparticle-based delivery methods for in vivo glial cell targeting." @default.
• W3133666077 created "2021-03-15" @default.
• W3133666077 creator A5020814680 @default.
• W3133666077 creator A5058296666 @default.
• W3133666077 creator A5059524816 @default.
• W3133666077 creator A5063249606 @default.
• W3133666077 creator A5069767796 @default.
• W3133666077 date "2021-03-03" @default.
• W3133666077 modified "2023-10-17" @default.
• W3133666077 title "Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System" @default.
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