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- W3133671448 abstract "TLC-bioautography amalgamated with hyphenated spectroscopy aid in precise in situ detection of secondary metabolites with pharmaceutical significance. TLC bioautography offers efficient and economical strategy in identifying compounds of interest from crude extracts. The present investigation has been focused on detection of antimicrobial metabolite from the culture broth of Nigrospora sphaerica inhabiting Croton bonplandianus Baill. The antimicrobial profiling confirmed the bioactive nigrosporalactone to possess broad-spectrum activity against test human pathogens with minimum inhibitory concentration values in the range 6.25 µg to 100 µg. The in silico studies revealed protein targets 1I01 (E. coli beta-ketoacyl reductase), 1IYL (C. albicans N-myristoyl transferase) had the highest binding score of -6.1 Kcal/mol." @default.
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- W3133671448 date "2021-07-01" @default.
- W3133671448 modified "2023-09-27" @default.
- W3133671448 title "TLC directed isolation and in silico analysis of antimicrobial metabolite from Nigrospora sphaerica inhabiting Croton bonplandianus Baill" @default.
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- W3133671448 doi "https://doi.org/10.1016/j.sajb.2021.01.035" @default.
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