FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133682034> ?p ?o ?g. }

• W3133682034 endingPage "679" @default.
• W3133682034 startingPage "662" @default.
• W3133682034 abstract "N6-methyladenosine (m6A) is found to be associated with promoting tumorigenesis in different types of cancers, however, the function of m6A-related genes in testicular germ cell tumors (TGCT) development remains to be illuminated. This study aimed to investigated the prognostic value of m6A RNA methylation regulators in TGCT.We collected TGCT patients' information about clinicopathologic parameters and twenty-two m6A regulatory genes expression from The Cancer Genome Atlas (TCGA) database and Genotype-Tissue Expression (GTEx). We analyzed the differentially expressed m6A RNA methylation regulators between tumor tissues and normal tissues, as well as the correlation of m6A RNA methylation regulators. By using Cox univariate analysis, last absolute shrinkage and selection operator (LASSO) Cox regression algorithm and Cox multivariate proportional hazards regression analysis, a risk score was constructed based on a TCGA training cohort, and further verified in the TCGA testing cohort. Then, univariate and multivariate Cox regression analyses were used to evaluate the relationship between risk score and progression-free survival (PFS) in TGCT. Finally, the six-gene risk score was further verified by two gene expression profiles (GSE3218 and GSE10783) as an independent external validation cohort.Distinct expression patterns of m6A regulatory genes were identified between TGCT tissues and normal tissues in TCGA and GTEx datasets. To predict prognosis of TGCT patients, a risk score was calculated based on six selected m6A RNA methylation regulators (YTHDF1, RBM15, IGF2BP1, ZC3H13, METTL3, and FMR1). Additionally, we found significant differences between the high-risk and low-risk groups in serum marker study levels and histologic subtype. Univariate and multivariate analysis indicated that high risk score was associated with unfavorable PFS. Ultimately, the risk score was further verified by two gene expression profiles (GSE3218 and GSE10783).Based on six selected m6A RNA methylation regulators, we developed a m6A methylation related risk score that can independently predict the prognosis of TGCT patients, and verify the prediction efficiency in TCGA and GEO datasets. Patients in high-risk group were associated with serum tumor marker study levels beyond the normal limits, non-seminoma, and unfavorable survival time. However, further prospective experiments should be carried out to verify our results." @default.
• W3133682034 created "2021-03-15" @default.
• W3133682034 creator A5009284558 @default.
• W3133682034 creator A5014687439 @default.
• W3133682034 creator A5024461381 @default.
• W3133682034 creator A5025814758 @default.
• W3133682034 creator A5042133353 @default.
• W3133682034 creator A5073779471 @default.
• W3133682034 creator A5075136340 @default.
• W3133682034 creator A5075496753 @default.
• W3133682034 creator A5089973740 @default.
• W3133682034 date "2021-02-01" @default.
• W3133682034 modified "2023-10-14" @default.
• W3133682034 title "m6A RNA methylation regulators play an important role in the prognosis of patients with testicular germ cell tumor" @default.
• W3133682034 cites W1501245729 @default.
• W3133682034 cites W1531373906 @default.
• W3133682034 cites W1757407923 @default.
• W3133682034 cites W1769875169 @default.
• W3133682034 cites W1981629946 @default.
• W3133682034 cites W1984705747 @default.
• W3133682034 cites W1985143881 @default.
• W3133682034 cites W1986988560 @default.
• W3133682034 cites W1994201724 @default.
• W3133682034 cites W2007208661 @default.
• W3133682034 cites W2026194232 @default.
• W3133682034 cites W2035905956 @default.
• W3133682034 cites W2058048803 @default.
• W3133682034 cites W2062750863 @default.
• W3133682034 cites W2065847836 @default.
• W3133682034 cites W2078964320 @default.
• W3133682034 cites W2097155839 @default.
• W3133682034 cites W2125063590 @default.
• W3133682034 cites W2130410032 @default.
• W3133682034 cites W2133370444 @default.
• W3133682034 cites W2140211014 @default.
• W3133682034 cites W2154427802 @default.
• W3133682034 cites W2165535625 @default.
• W3133682034 cites W2169501067 @default.
• W3133682034 cites W2187655448 @default.
• W3133682034 cites W2342299314 @default.
• W3133682034 cites W2533922074 @default.
• W3133682034 cites W2563912688 @default.
• W3133682034 cites W2578506026 @default.
• W3133682034 cites W2579378735 @default.
• W3133682034 cites W2600626962 @default.
• W3133682034 cites W2600862208 @default.
• W3133682034 cites W2754499625 @default.
• W3133682034 cites W2761676504 @default.
• W3133682034 cites W2768681263 @default.
• W3133682034 cites W2780167957 @default.
• W3133682034 cites W2791366345 @default.
• W3133682034 cites W2803154276 @default.
• W3133682034 cites W2897789847 @default.
• W3133682034 cites W2899264175 @default.
• W3133682034 cites W2914861971 @default.
• W3133682034 cites W2915777758 @default.
• W3133682034 cites W2922101574 @default.
• W3133682034 cites W2946110683 @default.
• W3133682034 cites W2950126013 @default.
• W3133682034 cites W2999533616 @default.
• W3133682034 cites W3003715948 @default.
• W3133682034 doi "https://doi.org/10.21037/tau-20-963" @default.
• W3133682034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7947426" @default.
• W3133682034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33718069" @default.
• W3133682034 hasPublicationYear "2021" @default.
• W3133682034 type Work @default.
• W3133682034 sameAs 3133682034 @default.
• W3133682034 citedByCount "10" @default.
• W3133682034 countsByYear W31336820342021 @default.
• W3133682034 countsByYear W31336820342022 @default.
• W3133682034 countsByYear W31336820342023 @default.
• W3133682034 crossrefType "journal-article" @default.
• W3133682034 hasAuthorship W3133682034A5009284558 @default.
• W3133682034 hasAuthorship W3133682034A5014687439 @default.
• W3133682034 hasAuthorship W3133682034A5024461381 @default.
• W3133682034 hasAuthorship W3133682034A5025814758 @default.
• W3133682034 hasAuthorship W3133682034A5042133353 @default.
• W3133682034 hasAuthorship W3133682034A5073779471 @default.
• W3133682034 hasAuthorship W3133682034A5075136340 @default.
• W3133682034 hasAuthorship W3133682034A5075496753 @default.
• W3133682034 hasAuthorship W3133682034A5089973740 @default.
• W3133682034 hasBestOaLocation W31336820341 @default.
• W3133682034 hasConcept C104317684 @default.
• W3133682034 hasConcept C105795698 @default.
• W3133682034 hasConcept C121608353 @default.
• W3133682034 hasConcept C126322002 @default.
• W3133682034 hasConcept C143998085 @default.
• W3133682034 hasConcept C150194340 @default.
• W3133682034 hasConcept C161584116 @default.
• W3133682034 hasConcept C190727270 @default.
• W3133682034 hasConcept C199163554 @default.
• W3133682034 hasConcept C2775963939 @default.
• W3133682034 hasConcept C2776212926 @default.
• W3133682034 hasConcept C2909856833 @default.
• W3133682034 hasConcept C2911180711 @default.
• W3133682034 hasConcept C33288867 @default.
• W3133682034 hasConcept C33923547 @default.
• W3133682034 hasConcept C50382708 @default.

• next