Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133685712> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3133685712 endingPage "7429" @default.
- W3133685712 startingPage "7416" @default.
- W3133685712 abstract "Fc fragment of IgG-binding protein (FCGBP) is differentially expressed in various tumors. However, the correlation between FCGBP and immune cell infiltration in ovarian cancer remains unclear. FCGBP expression was analyzed using The Cancer Genome Atlas (TCGA) pan-cancer data, and the ovarian cancer expression profile was analyzed using the Gene Expression Omnibus database. The clinical prognostic value of FCGBP was evaluated using clinical survival data from TCGA. Enrichment analysis of FCGBP was performed using the R package clusterProfiler. Based on known immune cell infiltration scores for samples found in TCGA, we analyzed the association between immune cell infiltration level and FCGBP expression. FCGBP was highly expressed and associated with poorer overall survival (p = 0.00051) and disease-specific survival (p = 0.0012) in ovarian cancer and other tumors. Additionally, high FCGBP expression correlated significantly with immune-related gene sets, including those involved in chemokine signaling pathways and innate and adaptive immunity. Further analysis showed that M2 macrophage infiltration increased and M1 macrophage infiltration decreased in tissues with high FCGBP expression. Our study suggests that FCGBP contributes to M2 macrophage polarization by acting as an oncogene in ovarian cancer. FCGBP may represent a clinically helpful biomarker for predicting overall survival of ovarian cancer patients." @default.
- W3133685712 created "2021-03-15" @default.
- W3133685712 creator A5000657831 @default.
- W3133685712 creator A5001251011 @default.
- W3133685712 creator A5012093966 @default.
- W3133685712 creator A5027058442 @default.
- W3133685712 creator A5056171934 @default.
- W3133685712 creator A5072723452 @default.
- W3133685712 creator A5073531557 @default.
- W3133685712 creator A5077821675 @default.
- W3133685712 date "2021-03-03" @default.
- W3133685712 modified "2023-09-23" @default.
- W3133685712 title "A bioinformatic analysis: the overexpression and clinical significance of FCGBP in ovarian cancer" @default.
- W3133685712 cites W1985987855 @default.
- W3133685712 cites W2039727733 @default.
- W3133685712 cites W2057589746 @default.
- W3133685712 cites W2141380480 @default.
- W3133685712 cites W2173279126 @default.
- W3133685712 cites W2345920029 @default.
- W3133685712 cites W2529607059 @default.
- W3133685712 cites W2756989878 @default.
- W3133685712 cites W2796207838 @default.
- W3133685712 cites W2910301764 @default.
- W3133685712 cites W2956024695 @default.
- W3133685712 cites W2959497269 @default.
- W3133685712 cites W3006260860 @default.
- W3133685712 cites W3014584745 @default.
- W3133685712 cites W3025139153 @default.
- W3133685712 cites W3025734729 @default.
- W3133685712 cites W3030279988 @default.
- W3133685712 cites W3035197553 @default.
- W3133685712 cites W3036478679 @default.
- W3133685712 cites W3037914953 @default.
- W3133685712 cites W3038035987 @default.
- W3133685712 cites W3048608175 @default.
- W3133685712 cites W3094820759 @default.
- W3133685712 doi "https://doi.org/10.18632/aging.202601" @default.
- W3133685712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7993703" @default.
- W3133685712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33686968" @default.
- W3133685712 hasPublicationYear "2021" @default.
- W3133685712 type Work @default.
- W3133685712 sameAs 3133685712 @default.
- W3133685712 citedByCount "18" @default.
- W3133685712 countsByYear W31336857122021 @default.
- W3133685712 countsByYear W31336857122022 @default.
- W3133685712 countsByYear W31336857122023 @default.
- W3133685712 crossrefType "journal-article" @default.
- W3133685712 hasAuthorship W3133685712A5000657831 @default.
- W3133685712 hasAuthorship W3133685712A5001251011 @default.
- W3133685712 hasAuthorship W3133685712A5012093966 @default.
- W3133685712 hasAuthorship W3133685712A5027058442 @default.
- W3133685712 hasAuthorship W3133685712A5056171934 @default.
- W3133685712 hasAuthorship W3133685712A5072723452 @default.
- W3133685712 hasAuthorship W3133685712A5073531557 @default.
- W3133685712 hasAuthorship W3133685712A5077821675 @default.
- W3133685712 hasBestOaLocation W31336857121 @default.
- W3133685712 hasConcept C121608353 @default.
- W3133685712 hasConcept C126322002 @default.
- W3133685712 hasConcept C143998085 @default.
- W3133685712 hasConcept C2780427987 @default.
- W3133685712 hasConcept C502942594 @default.
- W3133685712 hasConcept C63363279 @default.
- W3133685712 hasConcept C70721500 @default.
- W3133685712 hasConcept C71924100 @default.
- W3133685712 hasConcept C86803240 @default.
- W3133685712 hasConceptScore W3133685712C121608353 @default.
- W3133685712 hasConceptScore W3133685712C126322002 @default.
- W3133685712 hasConceptScore W3133685712C143998085 @default.
- W3133685712 hasConceptScore W3133685712C2780427987 @default.
- W3133685712 hasConceptScore W3133685712C502942594 @default.
- W3133685712 hasConceptScore W3133685712C63363279 @default.
- W3133685712 hasConceptScore W3133685712C70721500 @default.
- W3133685712 hasConceptScore W3133685712C71924100 @default.
- W3133685712 hasConceptScore W3133685712C86803240 @default.
- W3133685712 hasIssue "5" @default.
- W3133685712 hasLocation W31336857121 @default.
- W3133685712 hasLocation W31336857122 @default.
- W3133685712 hasOpenAccess W3133685712 @default.
- W3133685712 hasPrimaryLocation W31336857121 @default.
- W3133685712 hasRelatedWork W2069482181 @default.
- W3133685712 hasRelatedWork W2091020218 @default.
- W3133685712 hasRelatedWork W2130755392 @default.
- W3133685712 hasRelatedWork W2273141682 @default.
- W3133685712 hasRelatedWork W2353260778 @default.
- W3133685712 hasRelatedWork W2365364931 @default.
- W3133685712 hasRelatedWork W2418638721 @default.
- W3133685712 hasRelatedWork W2897496508 @default.
- W3133685712 hasRelatedWork W3034140415 @default.
- W3133685712 hasRelatedWork W3092079481 @default.
- W3133685712 hasVolume "13" @default.
- W3133685712 isParatext "false" @default.
- W3133685712 isRetracted "false" @default.
- W3133685712 magId "3133685712" @default.
- W3133685712 workType "article" @default.