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• W3133695618 endingPage "104314" @default.
• W3133695618 startingPage "104314" @default.
• W3133695618 abstract "In this paper, the heartbeat parameters of small model organisms, i.e. Drosophila melanogaster (fruit fly) and Danio rerio (zebrafish), were quantified in-vivo in intact larvae using microfluidics and a novel MATLAB-based software. Among different developmental stages of flies and zebrafish, the larval stage is privileged due to biological maturity, optical accessibility, and the myogenic nature of the heart. Conventional methods for parametric quantification of heart activities are complex and mostly done on dissected, irreversibly immobilized, or anesthetized larvae. Microfluidics has helped with reversible immobilization without the need for anesthesia, but heart monitoring is still done manually due to challenges associated with the movement of floating organs and cardiac interruptions. In our MATLAB software applied to videos recorded in microfluidic-based whole-organism assays, we have used image segmentation to automatically detect the heart and extract the heartbeat signal based on pixel intensity variations of the most contractile region of the heart tube. The smoothness priors approach (SPA) was applied to remove the undesired low-frequency noises caused by environmental light changes or heart movement. Heart rate and arrhythmicity were automatically measured from the detrended heartbeat signal while other parameters including end-diastolic and end-systolic diameters, shortening distance, shortening time, fractional shortening, and shortening velocity were quantified for the first time in intact larvae, using M-mode images under bright field microscopy. The software was able to detect more than 94% of the heartbeats and the cardiac arrests in intact Drosophila larvae. Our user-friendly software enables in-vivo quantification of D. melanogaster and D. rerio larval heart functions in microfluidic devices, with the potential to be applied to other biological models and used for automatic screening of drugs and alleles that affect their heart." @default.
• W3133695618 created "2021-03-15" @default.
• W3133695618 creator A5004972638 @default.
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• W3133695618 date "2021-05-01" @default.
• W3133695618 modified "2023-10-01" @default.
• W3133695618 title "Open access tool and microfluidic devices for phenotypic quantification of heart function of intact fruit fly and zebrafish larvae" @default.
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• W3133695618 doi "https://doi.org/10.1016/j.compbiomed.2021.104314" @default.
• W3133695618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33774273" @default.
• W3133695618 hasPublicationYear "2021" @default.
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