Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133701908> ?p ?o ?g. }
- W3133701908 endingPage "107830" @default.
- W3133701908 startingPage "107830" @default.
- W3133701908 abstract "Atopic dermatitis (AD) is an inflammatory skin disease arising from a complex interplay of genetic, immune, and environmental factors. The development and successful marketing of the anti-IL-4/IL-13 monoclonal antibody, dupilumab, and the topical nonsteroidal phosphodiesterase 4 (PDE4) inhibitor, crisaborole, as well as the Janus kinase (JAK) inhibitor, delgocitinib, have brought hope for developing new therapeutic agents. The efficacy of these treatments contributes to our understanding of the pathophysiology of AD. Dupilumab modulates the Th2-related immune response, demonstrating that IL-4 and IL-13 contribute to epidermal hyperplasia, skin homeostasis, and innate immune responses on the skin surface in AD. The effectiveness of crisaborole reveals that PDE4 contributes to Th2 and Th17/Th22 inflammation and lesional skin barrier dysfunction, while delgocitinib shows that JAK-associated signaling is essential for the inflammatory reaction in AD. This review provides a brief overview of recent research on therapeutic monoclonal antibodies and small biologic molecules for AD and what these treatments reveal about AD pathophysiology." @default.
- W3133701908 created "2021-03-15" @default.
- W3133701908 creator A5008916495 @default.
- W3133701908 creator A5023533946 @default.
- W3133701908 creator A5032808163 @default.
- W3133701908 creator A5056726482 @default.
- W3133701908 date "2021-08-01" @default.
- W3133701908 modified "2023-09-29" @default.
- W3133701908 title "Advances in the pathophysiology of atopic dermatitis revealed by novel therapeutics and clinical trials" @default.
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