Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133714594> ?p ?o ?g. }
- W3133714594 abstract "Significance Many current vaccines seek to elicit protective antibody responses along precise evolutionary pathways, and a fundamental understanding of genetic, structural, and biophysical antibody development features will accelerate guided vaccine strategies. Here we determine the structural and biophysical features associated with improvement or fitness of an antibody targeting the HIV fusion peptide, a known vulnerable site on HIV-1. We show that around 1% of possible antibody mutations can improve virus recognition. Beneficial mutations were often clustered far from the binding interface and altered protein structure and dynamics, leading to reduced antibody thermal stability and higher binding affinity to the HIV envelope trimer. These data quantify the genetic and biophysical landscape for improvement of a vaccine-elicted antibody and provide a rational framework to guide HIV vaccines." @default.
- W3133714594 created "2021-03-15" @default.
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- W3133714594 date "2021-03-01" @default.
- W3133714594 modified "2023-10-18" @default.
- W3133714594 title "Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody" @default.
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