FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133722772> ?p ?o ?g. }

• W3133722772 abstract "The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs following induction of thermal injury. These neutrophils expressed elevated levels of programmed death ligand 1 (PD-L1) and exhibited altered gene expression profiles indicative of a reparative population. Upon injury, neutrophils migrate from the bone marrow to the skin but transiently arrest in the lung vasculature. Arrested neutrophils interact with programmed cell death protein 1 (PD-1) on lung endothelial cells. A period of susceptibility to infection is linked to PD-L1+ neutrophil accumulation in the lung. Systemic treatment of injured animals with an anti-PD-L1 antibody prevented neutrophil accumulation in the lung and reduced susceptibility to infection but augmented skin healing, resulting in increased epidermal growth. This work provides evidence that injury promotes changes to neutrophils that are important for wound healing but contribute to infection susceptibility." @default.
• W3133722772 created "2021-03-15" @default.
• W3133722772 creator A5005264713 @default.
• W3133722772 creator A5010152262 @default.
• W3133722772 creator A5010213527 @default.
• W3133722772 creator A5013106324 @default.
• W3133722772 creator A5025284770 @default.
• W3133722772 creator A5031609759 @default.
• W3133722772 creator A5034002721 @default.
• W3133722772 creator A5034101434 @default.
• W3133722772 creator A5034298867 @default.
• W3133722772 creator A5037668891 @default.
• W3133722772 creator A5050859911 @default.
• W3133722772 creator A5051353753 @default.
• W3133722772 creator A5051993142 @default.
• W3133722772 creator A5059440505 @default.
• W3133722772 creator A5059756742 @default.
• W3133722772 creator A5062517466 @default.
• W3133722772 creator A5067889391 @default.
• W3133722772 creator A5075072986 @default.
• W3133722772 creator A5077367742 @default.
• W3133722772 creator A5078346266 @default.
• W3133722772 creator A5078998694 @default.
• W3133722772 date "2021-03-05" @default.
• W3133722772 modified "2023-10-14" @default.
• W3133722772 title "PD-L1 ⁺ neutrophils contribute to injury-induced infection susceptibility" @default.
• W3133722772 cites W1598145397 @default.
• W3133722772 cites W1600560134 @default.
• W3133722772 cites W1969675688 @default.
• W3133722772 cites W1973431219 @default.
• W3133722772 cites W1989066917 @default.
• W3133722772 cites W1998356393 @default.
• W3133722772 cites W2032901225 @default.
• W3133722772 cites W2035122148 @default.
• W3133722772 cites W2051721450 @default.
• W3133722772 cites W2068854215 @default.
• W3133722772 cites W2072805330 @default.
• W3133722772 cites W2073113196 @default.
• W3133722772 cites W2104017463 @default.
• W3133722772 cites W2111893100 @default.
• W3133722772 cites W2133088243 @default.
• W3133722772 cites W2133374150 @default.
• W3133722772 cites W2138787512 @default.
• W3133722772 cites W2141774394 @default.
• W3133722772 cites W2142115916 @default.
• W3133722772 cites W2290890702 @default.
• W3133722772 cites W2526244009 @default.
• W3133722772 cites W2620241325 @default.
• W3133722772 cites W2761821009 @default.
• W3133722772 cites W2770395397 @default.
• W3133722772 cites W2774212996 @default.
• W3133722772 cites W2780648853 @default.
• W3133722772 cites W2791633954 @default.
• W3133722772 cites W2792366526 @default.
• W3133722772 cites W2803017273 @default.
• W3133722772 cites W2906111025 @default.
• W3133722772 cites W2947029606 @default.
• W3133722772 cites W2970080540 @default.
• W3133722772 cites W2977648831 @default.
• W3133722772 cites W2998582467 @default.
• W3133722772 cites W3013771087 @default.
• W3133722772 doi "https://doi.org/10.1126/sciadv.abd9436" @default.
• W3133722772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7935370" @default.
• W3133722772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33674305" @default.
• W3133722772 hasPublicationYear "2021" @default.
• W3133722772 type Work @default.
• W3133722772 sameAs 3133722772 @default.
• W3133722772 citedByCount "13" @default.
• W3133722772 countsByYear W31337227722021 @default.
• W3133722772 countsByYear W31337227722022 @default.
• W3133722772 countsByYear W31337227722023 @default.
• W3133722772 crossrefType "journal-article" @default.
• W3133722772 hasAuthorship W3133722772A5005264713 @default.
• W3133722772 hasAuthorship W3133722772A5010152262 @default.
• W3133722772 hasAuthorship W3133722772A5010213527 @default.
• W3133722772 hasAuthorship W3133722772A5013106324 @default.
• W3133722772 hasAuthorship W3133722772A5025284770 @default.
• W3133722772 hasAuthorship W3133722772A5031609759 @default.
• W3133722772 hasAuthorship W3133722772A5034002721 @default.
• W3133722772 hasAuthorship W3133722772A5034101434 @default.
• W3133722772 hasAuthorship W3133722772A5034298867 @default.
• W3133722772 hasAuthorship W3133722772A5037668891 @default.
• W3133722772 hasAuthorship W3133722772A5050859911 @default.
• W3133722772 hasAuthorship W3133722772A5051353753 @default.
• W3133722772 hasAuthorship W3133722772A5051993142 @default.
• W3133722772 hasAuthorship W3133722772A5059440505 @default.
• W3133722772 hasAuthorship W3133722772A5059756742 @default.
• W3133722772 hasAuthorship W3133722772A5062517466 @default.
• W3133722772 hasAuthorship W3133722772A5067889391 @default.
• W3133722772 hasAuthorship W3133722772A5075072986 @default.
• W3133722772 hasAuthorship W3133722772A5077367742 @default.
• W3133722772 hasAuthorship W3133722772A5078346266 @default.
• W3133722772 hasAuthorship W3133722772A5078998694 @default.
• W3133722772 hasBestOaLocation W31337227721 @default.
• W3133722772 hasConcept C126322002 @default.
• W3133722772 hasConcept C170493617 @default.
• W3133722772 hasConcept C190283241 @default.
• W3133722772 hasConcept C203014093 @default.
• W3133722772 hasConcept C2776914184 @default.
• W3133722772 hasConcept C2777714996 @default.

• next