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• W3133723108 abstract "The sequences of SARS-CoV-2 spike (S) from Saudi Arabia along with SARS-CoV and bat SARS-like CoVs were obtained. Positive selection analysis and secondary structure investigation of spike sequences were performed. Adaptive molecular evolution was observed in SARS-CoV-2 displayed by positive selection pressure at N-terminal domain (NTD; codons 41, 163, 174 and 218), Receptor binding domain (RBD; codons 378 and 404) and S1/S2 Cleavage site (codon 690). Furthermore, the spike protein secondary structure depicted by the homo-trimer structure showed a high similarity between Saudi SARS-CoV-2 isolate and the parental strain (bat SL-COVZC45). Despite the high similarity depicted in the spike sequence model alignment, it displayed a significant difference when each chain was treated solely owing to 7 motif differences in the three composing chains. In addition, SARS-CoV-2 S trimer model uncovered the presence of N-acetyl glucosamine ligands. Eventually, 3C-like proteinase cleavage site was observed in S2 domain could be used as a site for drug discovery. Genetics and molecular evolutionary facts are useful for assessment of evolution, host adaptation and epidemic patterns ultimately helpful for adaptation of control strategies." @default.
• W3133723108 created "2021-03-15" @default.
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• W3133723108 date "2021-06-01" @default.
• W3133723108 modified "2023-10-18" @default.
• W3133723108 title "Molecular adaptive evolution of SARS-COV-2 spike protein in Saudi Arabia" @default.
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• W3133723108 doi "https://doi.org/10.1016/j.sjbs.2021.02.077" @default.
• W3133723108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7923870" @default.
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