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- W3133727424 abstract "This study assessed the safety of adalimumab in different dosages and durations of treatment.We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to explore the infection risk in people who received adalimumab. We searched the Cochrane Library, PubMed, and EMBASE from inception to December 8, 2020. Summary estimates were obtained using meta-analysis with a random-effects model.Twenty-one RCTs, considered to be of high quality, were analyzed. We found that there was a risk of infection (RR: 1.10, 95% CI: 1.02-1.18). In the stratified analysis, we found an increase in infection among those that received normal dosage (RR: 1.13, 95% CI: 1.04-1.23), and in patients with psoriasis (RR: 1.13, 95% CI: 1.00-1.35) and rheumatoid arthritis (RR: 1.23, 95% CI: 1.06-1.41), but not in those that received high doses and other criteria. In the meta-regressions, intervention duration was not related to changes in incidence risk.Trials that have a longer treatment duration and higher doses are needed to clarify whether patients that received adalimumab had an elevated risk of general infection." @default.
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- W3133727424 date "2021-04-13" @default.
- W3133727424 modified "2023-10-17" @default.
- W3133727424 title "Effect of adalimumab interventions on general infection among adults: a systematic review and meta-analysis of randomized controlled trials" @default.
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- W3133727424 doi "https://doi.org/10.1080/14787210.2021.1902804" @default.
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