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- W3133738836 endingPage "323" @default.
- W3133738836 startingPage "255" @default.
- W3133738836 abstract "This chapter discusses amino acid transporters (carriers) of epithelial barriers and glands and their localization and function. We consider this array of solute carrier members from seven different SLC families with overlapping selectivity and different transport modes. Corresponding knockout mouse models are mentioned and we discuss then, in more detail, the transport in exocrine pancreas, small intestine, and kidney proximal tubule. In acinar cells of the pancreas that form a typical secretory epithelium, several antiporters with overlapping selectivity cooperate with Na+ symporters, selective for nonessential amino acids, to actively accumulate all amino acids required for the synthesis of digestive enzymes and amino acid secretion. In kidney proximal tubule and small intestine epithelial cells, a mostly common set of transporters (re)absorbs amino acids from the lumen into the “milieu interieur” (extracellular space). While luminal Na+- and H+-dependent symporters together with an antiporter actively import all amino acids across the apical membrane, basolateral uniporters selective for essential amino acids cooperate with broad selectivity antiporters to mediate the controlled efflux of amino acids. These latter transporters thereby maintain intracellular homeostasis including a high concentration of nonessential amino acids. This chapter further discusses the newest findings on the regulation of amino acid transporters and, in some cases, the effect of transporter ablation on organ function." @default.
- W3133738836 created "2021-03-15" @default.
- W3133738836 creator A5015311189 @default.
- W3133738836 creator A5053938475 @default.
- W3133738836 creator A5073423737 @default.
- W3133738836 date "2020-01-01" @default.
- W3133738836 modified "2023-09-27" @default.
- W3133738836 title "Amino Acid Transporters of Epithelia" @default.
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