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• W3133743290 abstract "The connector protein, also known as the portal protein, located at the portal vertex in the Phi29 bacteriophage has been found to play a key role in the genome DNA packaging motor. There is a disordered region, composed of 12 sets of 18-residue loops N229-N246, that has been assumed to serve as a clamp to retain the DNA within the pressurized capsid when DNA is fully packaged. However, the process remains undefined about how the clamping of DNA occurs and what signal is used to engage the channel loops to clamp the DNA near the end of DNA packaging. In this study, we use the planar lipid bilayer (PLB) membrane technique to study the connector with its loops cleaved. The channel properties are compared with those of the connector with corresponding wild-type loops at different membrane potentials. On the basis of the hypothesis of the Donnan effects in the flashing Brownian ratchet model, we associate the PLB experimental results with the outcomes from the relevant biochemical experiments on the proheads containing the connectors without the loops, which enables us to provide a clear picture about how the DNA clamping occurs. A mathematical relationship between the Donnan potential and the DNA packaging density is established, demonstrating that they are both in essence the same signal that is received and transmitted by the connector to dictate DNA clamping and the termination of DNA packaging. At the end of the study, the PLB technique is proposed as a viral research tool, and its potential use to study the functions of specific domains in a portal protein of the tailed bacteriophages is highlighted." @default.
• W3133743290 created "2021-03-15" @default.
• W3133743290 creator A5036854662 @default.
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• W3133743290 date "2021-05-01" @default.
• W3133743290 modified "2023-10-16" @default.
• W3133743290 title "The PLB measurement for the connector in Phi29 bacteriophage reveals the function of its channel loop" @default.
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• W3133743290 doi "https://doi.org/10.1016/j.bpj.2021.02.043" @default.
• W3133743290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8204335" @default.
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• W3133743290 hasPublicationYear "2021" @default.
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