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- W3133760949 endingPage "16" @default.
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- W3133760949 abstract "This review discusses our current knowledge on the nociceptin/orphanin (N/OFQ) system regarding its role in regulation of brain functions. Nociceptin receptor (NOPr) was identified in 1994 [Bunzow et al., 1994; Mollereau et al., 1994]. In 1995 a 17 amino acid endogenous peptide was found to be the high-affinity ligand for the NOPr [Reinscheid et al., 1995]. N/OFQ has a broad spectrum of activity and can act as on opioid-like as well as an anti-opioid peptide. Considering high level of N/OFQ and NOPr mRNA expression in the limbic brain regions, the N/OFQ/NOP system is suggested to be involved in regulation of emotions, resward, pain sensitivity, stress responsibility, sexual behavior, aggression, drug abuse and addiction. However it is still not well understood whether an increased vulnerability to drugs of abuse may be associated with dysregulation of N/OFQ/NOP system. Current review further highlights a need for further research on N/OFQ/NOP system as it could have clinical utility for substance abuse, depression, and anxiety pharmacotherapy." @default.
- W3133760949 created "2021-03-15" @default.
- W3133760949 creator A5025660512 @default.
- W3133760949 creator A5035857650 @default.
- W3133760949 creator A5037949586 @default.
- W3133760949 creator A5055355716 @default.
- W3133760949 creator A5061266450 @default.
- W3133760949 date "2021-01-01" @default.
- W3133760949 modified "2023-09-26" @default.
- W3133760949 title "The role of nociceptin in opioid regulation of brain functions" @default.
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