FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133763207> ?p ?o ?g. }

• W3133763207 endingPage "344" @default.
• W3133763207 startingPage "344" @default.
• W3133763207 abstract "Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer ratio (Polyvinylpyrrolidione-vinyl acetate 64, 1:1–1:4) and barrel temperature (200–240 °C), fixed at 20% of Cremophor® RH 40 and 15 rpm of the screw speed, using the hot-melt extruding technique. This study evaluates the solubility, dissolution behavior, and bioavailability for application to oral drug delivery and optimizes the formulation of rivaroxaban amorphous solid dispersion (RXB-ASD). Based on a central composite design, optimized RXB-ASD (PVP VA 64 ratio 1:4.1, barrel temperature 216.1 °C, Cremophor® RH 40 20%, screw speed 15 rpm) showed satisfactory results for dependent variables. An in vitro drug dissolution study exhibited relatively high dissolution in four media and achieved around an 80% cumulative drug release in 120 min. Optimized RXB-ASD was stable under the accelerated condition for three months without a change in crystallinity and the dissolution rate. A pharmacokinetic study of RXB-ASD in rats showed that the absorption was markedly increased in terms of rate and amount, i.e., the systemic exposure values, compared to raw RXB powder. These results showed the application of quality by design (QbD) in the formulation development of hot-melt extruded RXB-ASD, which can be used as an oral drug delivery system by increasing the dissolution rate and bioavailability." @default.
• W3133763207 created "2021-03-15" @default.
• W3133763207 creator A5002562123 @default.
• W3133763207 creator A5007204051 @default.
• W3133763207 creator A5020202813 @default.
• W3133763207 creator A5030577718 @default.
• W3133763207 creator A5040593274 @default.
• W3133763207 creator A5071196793 @default.
• W3133763207 creator A5078753157 @default.
• W3133763207 date "2021-03-06" @default.
• W3133763207 modified "2023-10-16" @default.
• W3133763207 title "The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing Rivaroxaban in Combination with Polymers" @default.
• W3133763207 cites W1505181639 @default.
• W3133763207 cites W1989295556 @default.
• W3133763207 cites W1994618196 @default.
• W3133763207 cites W2008223612 @default.
• W3133763207 cites W2026872442 @default.
• W3133763207 cites W2028162842 @default.
• W3133763207 cites W2028895013 @default.
• W3133763207 cites W2051488350 @default.
• W3133763207 cites W2061510929 @default.
• W3133763207 cites W2078493246 @default.
• W3133763207 cites W2085219848 @default.
• W3133763207 cites W2088560132 @default.
• W3133763207 cites W2115439624 @default.
• W3133763207 cites W2119961487 @default.
• W3133763207 cites W2130622649 @default.
• W3133763207 cites W2140581145 @default.
• W3133763207 cites W2165290439 @default.
• W3133763207 cites W2167286960 @default.
• W3133763207 cites W2327186139 @default.
• W3133763207 cites W2338510100 @default.
• W3133763207 cites W2529408514 @default.
• W3133763207 cites W2537122513 @default.
• W3133763207 cites W2775991828 @default.
• W3133763207 cites W2892780624 @default.
• W3133763207 cites W2923501994 @default.
• W3133763207 cites W2941811147 @default.
• W3133763207 cites W2985253493 @default.
• W3133763207 cites W2992007157 @default.
• W3133763207 cites W2996306650 @default.
• W3133763207 doi "https://doi.org/10.3390/pharmaceutics13030344" @default.
• W3133763207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8001048" @default.
• W3133763207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33800741" @default.
• W3133763207 hasPublicationYear "2021" @default.
• W3133763207 type Work @default.
• W3133763207 sameAs 3133763207 @default.
• W3133763207 citedByCount "9" @default.
• W3133763207 countsByYear W31337632072022 @default.
• W3133763207 countsByYear W31337632072023 @default.
• W3133763207 crossrefType "journal-article" @default.
• W3133763207 hasAuthorship W3133763207A5002562123 @default.
• W3133763207 hasAuthorship W3133763207A5007204051 @default.
• W3133763207 hasAuthorship W3133763207A5020202813 @default.
• W3133763207 hasAuthorship W3133763207A5030577718 @default.
• W3133763207 hasAuthorship W3133763207A5040593274 @default.
• W3133763207 hasAuthorship W3133763207A5071196793 @default.
• W3133763207 hasAuthorship W3133763207A5078753157 @default.
• W3133763207 hasBestOaLocation W31337632071 @default.
• W3133763207 hasConcept C116073593 @default.
• W3133763207 hasConcept C120665830 @default.
• W3133763207 hasConcept C121332964 @default.
• W3133763207 hasConcept C127413603 @default.
• W3133763207 hasConcept C155574463 @default.
• W3133763207 hasConcept C159985019 @default.
• W3133763207 hasConcept C160492267 @default.
• W3133763207 hasConcept C164705383 @default.
• W3133763207 hasConcept C177562468 @default.
• W3133763207 hasConcept C178790620 @default.
• W3133763207 hasConcept C181389837 @default.
• W3133763207 hasConcept C185592680 @default.
• W3133763207 hasConcept C192562407 @default.
• W3133763207 hasConcept C202751555 @default.
• W3133763207 hasConcept C2776301958 @default.
• W3133763207 hasConcept C2778661090 @default.
• W3133763207 hasConcept C2779161974 @default.
• W3133763207 hasConcept C2781430271 @default.
• W3133763207 hasConcept C2910701995 @default.
• W3133763207 hasConcept C42360764 @default.
• W3133763207 hasConcept C43617362 @default.
• W3133763207 hasConcept C46275449 @default.
• W3133763207 hasConcept C55493867 @default.
• W3133763207 hasConcept C56052488 @default.
• W3133763207 hasConcept C71924100 @default.
• W3133763207 hasConcept C88380143 @default.
• W3133763207 hasConcept C98274493 @default.
• W3133763207 hasConceptScore W3133763207C116073593 @default.
• W3133763207 hasConceptScore W3133763207C120665830 @default.
• W3133763207 hasConceptScore W3133763207C121332964 @default.
• W3133763207 hasConceptScore W3133763207C127413603 @default.
• W3133763207 hasConceptScore W3133763207C155574463 @default.
• W3133763207 hasConceptScore W3133763207C159985019 @default.
• W3133763207 hasConceptScore W3133763207C160492267 @default.
• W3133763207 hasConceptScore W3133763207C164705383 @default.
• W3133763207 hasConceptScore W3133763207C177562468 @default.
• W3133763207 hasConceptScore W3133763207C178790620 @default.
• W3133763207 hasConceptScore W3133763207C181389837 @default.
• W3133763207 hasConceptScore W3133763207C185592680 @default.

• next